Thy-1 antigen expression by murine hematopoietic precursor cells

J. W. Berman, R. S. Basch

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Multiple lymphohematopoietic stem cells detected by a 12-day spleen colony assay are uniformly Thy-1 positive. As these cells differentiate into stem cells with restricted developmental potential, the antigen is lost. The various restricted progenitor cells differ in their susceptibility to the cytolytic effects of anti-Thy-1 antiserum. Erythroid progenitors appear to lose the antigen more rapidly than any of the others tested, while macrophage precursors retain the antigen until relatively late in their developmental history. These differences in Thy-1 expression permit discrimination among the various progenitors.

Original languageEnglish (US)
Pages (from-to)1152-1156
Number of pages5
JournalExperimental Hematology
Volume13
Issue number11
StatePublished - Dec 1 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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