Thrombotic thrombocytopenic purpura in pregnancy: Successful treatment with plasma exchange

Michele H. Mokrzycki, Frederick R. Rickles, Andre A. Kaplan, Orly F. Kohn

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a rare syndrome which presents typically with thrombocytopenia, microangiopathic hemolytic anemia, central nervous system symptoms, fever, and renal abnormalities. The diagnosis of TTP in pregnancy previously carried a poor prognosis and a high fetal mortality when presenting early in gestation. This case report describes the earliest presentation of TTP in pregnancy (6 weeks of gestation) we could identify in the literature treated successfully with a prolonged course of plasma exchange. The differential diagnosis and the pathogenesis of TTP in pregnancy are reviewed. Therapeutic options and data regarding the removal of pregnancy-related hormones by plasma exchange are presented.

Original languageEnglish (US)
Pages (from-to)271-282
Number of pages12
JournalBlood Purification
Volume13
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Thrombotic Thrombocytopenic Purpura
Plasma Exchange
Pregnancy
Therapeutics
Fetal Mortality
Hemolytic Anemia
Thrombocytopenia
Differential Diagnosis
Fever
Central Nervous System
Hormones
Kidney

Keywords

  • Plasma exchange
  • Plasmapheresis
  • Pregnancy
  • Purpura
  • Thrombocytopenic
  • Thrombotic

ASJC Scopus subject areas

  • Hematology
  • Nephrology

Cite this

Thrombotic thrombocytopenic purpura in pregnancy : Successful treatment with plasma exchange. / Mokrzycki, Michele H.; Rickles, Frederick R.; Kaplan, Andre A.; Kohn, Orly F.

In: Blood Purification, Vol. 13, No. 5, 1995, p. 271-282.

Research output: Contribution to journalArticle

Mokrzycki, Michele H. ; Rickles, Frederick R. ; Kaplan, Andre A. ; Kohn, Orly F. / Thrombotic thrombocytopenic purpura in pregnancy : Successful treatment with plasma exchange. In: Blood Purification. 1995 ; Vol. 13, No. 5. pp. 271-282.
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