Three-dimensional ultrasound of the neonatal brain: technical approach and spectrum of disease

Jessica Kurian Joseph, Susan Sotardi, Mark C. Liszewski, William A. Gomes, Thomas Hoffman, Benjamin H. Taragin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Brain pathology is an important cause of morbidity and mortality in neonates, especially in the premature population. While conventional two-dimensional neurosonography is traditionally used for screening, diagnosis and monitoring of brain disorders such as germinal matrix hemorrhage, periventricular leukomalacia and hydrocephalus, three-dimensional ultrasonography has gained popularity in a variety of clinical applications in recent years. Three-dimensional ultrasonography is not yet widely utilized in pediatric imaging but is a potentially powerful tool for evaluating the neonatal brain. Three-dimensional neurosonography allows imaging of the entire brain in a single volumetric sweep and offers the capability of reconstructing images in the axial plane and performing volumetric analyses that are unavailable in conventional two-dimensional neurosonography. The purpose of this article is two-fold: (1) to present the technical aspects of three-dimensional neurosonography and (2) to illustrate the potential applications of three-dimensional neurosonography in the context of commonly encountered neonatal neuropathology.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalPediatric Radiology
StateAccepted/In press - Jan 5 2017


  • Brain
  • Neonate
  • Neurosonography
  • Prematurity
  • Three-dimensional ultrasonography
  • Ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging


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