TY - JOUR
T1 - Thin Lipid Membranes
T2 - A Model for Cell Membranes
AU - Finkelstein, Alan
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1972/2
Y1 - 1972/2
N2 - The permeability properties of “unmodified” thin (≪ 100 Angstroms) lipid membranes separating two aqueous phases are those expected of a thin layer of hydrocarbon. Certain molecules interact with these membranes to enormously increase their permeability to ions and hydrophilic nonelectrolytes. Some of these molecules function as cation carriers with high specificity for K+ over Na+; some create aqueous pores approximately 4A in radius; others create strongly voltage-dependent conductance sites that can give rise to action potentials kinetically similar to those of nerve and muscle. These agents produce local modifications occupying a small fraction of the membrane area; ie, the “modified” membrane is a mosaic structure. Permeability and pharmacological data demonstrate that plasma membranes are also mosaic structures. If the Davson-Danielli model of plasma membranes is essentially correct, modified thin lipid membranes are both phenomenologically and structurally an excellent model for biological membranes.
AB - The permeability properties of “unmodified” thin (≪ 100 Angstroms) lipid membranes separating two aqueous phases are those expected of a thin layer of hydrocarbon. Certain molecules interact with these membranes to enormously increase their permeability to ions and hydrophilic nonelectrolytes. Some of these molecules function as cation carriers with high specificity for K+ over Na+; some create aqueous pores approximately 4A in radius; others create strongly voltage-dependent conductance sites that can give rise to action potentials kinetically similar to those of nerve and muscle. These agents produce local modifications occupying a small fraction of the membrane area; ie, the “modified” membrane is a mosaic structure. Permeability and pharmacological data demonstrate that plasma membranes are also mosaic structures. If the Davson-Danielli model of plasma membranes is essentially correct, modified thin lipid membranes are both phenomenologically and structurally an excellent model for biological membranes.
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U2 - 10.1001/archinte.1972.00320020073005
DO - 10.1001/archinte.1972.00320020073005
M3 - Article
C2 - 5058549
AN - SCOPUS:0015290513
SN - 0003-9926
VL - 129
SP - 229
EP - 240
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 2
ER -