Thermodynamic studies of lectin-carbohydrate interactions by isothermal titration calorimetry

Tarun K. Dam, C. Fred Brewer

Research output: Contribution to journalArticle

402 Scopus citations


The isothermal titration calorimetry (ITC) measurements became an important and widely used method for investigating the thermodynamics of carbohydrate-lectin interactions. Thus, no other method affords the ease of directly determining thermodynamic binding parameters without modifying the carbohydrates or proteins of interest. This paper summarizes a wide range of lectin binding studies investigated by ITC during the past decade.

Original languageEnglish (US)
Pages (from-to)387-429
Number of pages43
JournalChemical Reviews
Issue number2
StatePublished - Feb 1 2002


ASJC Scopus subject areas

  • Chemistry(all)

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