Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain

Ranjitha Katikaneni, Andrew W. Seymour, Rohan Gulati, Tulasi Ponnapakkam, Robert C. Gensure

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Alopecia areata is a common disorder in which autoimmune destruction of hair follicles results in patchy hair loss. Currently there is no adequate therapy, although immune modulator therapies are currently in development. Parathyroid hormone (PTH) is a hair cycle stimulator which shows promise in treating various forms of alopecia, although its short half-life limits its clinical use. PTH-CBD is a PTH analog which binds collagen, prolonging retention in skin. We tested effects of PTH-CBD in C3H/HeJ-engrafted mice, the animal model for alopecia areata, on hair growth and found that a significant proportion of animals had reduced hair loss (PTH-CBD: 13/21, 62% vs. control: 3/10, 30%; P

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Alopecia Areata
Parathyroid Hormone
Hair
Collagen
Alopecia
Therapeutics
Hair Follicle
Half-Life
Animal Models
Skin
Growth

ASJC Scopus subject areas

  • Dermatology
  • Biotechnology
  • Molecular Biology
  • Cell Biology

Cite this

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title = "Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain",
abstract = "Alopecia areata is a common disorder in which autoimmune destruction of hair follicles results in patchy hair loss. Currently there is no adequate therapy, although immune modulator therapies are currently in development. Parathyroid hormone (PTH) is a hair cycle stimulator which shows promise in treating various forms of alopecia, although its short half-life limits its clinical use. PTH-CBD is a PTH analog which binds collagen, prolonging retention in skin. We tested effects of PTH-CBD in C3H/HeJ-engrafted mice, the animal model for alopecia areata, on hair growth and found that a significant proportion of animals had reduced hair loss (PTH-CBD: 13/21, 62{\%} vs. control: 3/10, 30{\%}; P",
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AU - Katikaneni, Ranjitha

AU - Seymour, Andrew W.

AU - Gulati, Rohan

AU - Ponnapakkam, Tulasi

AU - Gensure, Robert C.

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