TY - JOUR
T1 - Therapeutic potential of naringin in neurological disorders
AU - Ahmed, Salman
AU - Khan, Haroon
AU - Aschner, Michael
AU - Hasan, Muhammad Mohtasheemul
AU - Hassan, Sherif T.S.
N1 - Publisher Copyright:
© 2019
PY - 2019/10
Y1 - 2019/10
N2 - Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative therapy for the treatment of various neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin and naringin (NRG) have been shown to possess promising potential in the treatment of neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and different possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.
AB - Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative therapy for the treatment of various neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin and naringin (NRG) have been shown to possess promising potential in the treatment of neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and different possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.
KW - Antineuroinflammation
KW - Antioxidant
KW - Naringin antiapoptotic
KW - Neuroprotective
KW - Polyphenols
UR - http://www.scopus.com/inward/record.url?scp=85067879258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067879258&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2019.110646
DO - 10.1016/j.fct.2019.110646
M3 - Review article
C2 - 31252025
AN - SCOPUS:85067879258
SN - 0278-6915
VL - 132
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 110646
ER -