Therapeutic potential of naringin in neurological disorders

Salman Ahmed, Haroon Khan, Michael Aschner, Muhammad Mohtasheemul Hasan, Sherif T.S. Hassan

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative therapy for the treatment of various neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin and naringin (NRG) have been shown to possess promising potential in the treatment of neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and different possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.

Original languageEnglish (US)
Article number110646
JournalFood and Chemical Toxicology
Volume132
DOIs
StatePublished - Oct 1 2019

Fingerprint

naringin
nervous system diseases
Nervous System Diseases
therapeutics
Neuroprotective Agents
neuroprotective effect
alternative medicine
myricetin
Curcumin
curcumin
resveratrol
Polyphenols
Therapeutics
Complementary Therapies
Biological Products
clinical trials
polyphenols
Clinical Trials
Molecules

Keywords

  • Antineuroinflammation
  • Antioxidant
  • Naringin antiapoptotic
  • Neuroprotective
  • Polyphenols

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Therapeutic potential of naringin in neurological disorders. / Ahmed, Salman; Khan, Haroon; Aschner, Michael; Hasan, Muhammad Mohtasheemul; Hassan, Sherif T.S.

In: Food and Chemical Toxicology, Vol. 132, 110646, 01.10.2019.

Research output: Contribution to journalReview article

Ahmed, Salman ; Khan, Haroon ; Aschner, Michael ; Hasan, Muhammad Mohtasheemul ; Hassan, Sherif T.S. / Therapeutic potential of naringin in neurological disorders. In: Food and Chemical Toxicology. 2019 ; Vol. 132.
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