Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights

Salman Ahmed, Waqas Alam, Philippe Jeandet, Michael Aschner, Khalaf F. Alsharif, Luciano Saso, Haroon Khan

Research output: Contribution to journalReview articlepeer-review

Abstract

Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa.

Original languageEnglish (US)
Article number466
JournalMarine Drugs
Volume20
Issue number8
DOIs
StatePublished - Aug 2022

Keywords

  • antiangiogenic
  • antimetastatic
  • antimitotic
  • apoptosis
  • cell cycle arrest
  • marine peptides

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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