Abstract
Growing evidence indicates that the presence of extensive oxidative stress plays an essential role in the initiation and progression of Alzheimer’s disease (AD). Amyloid-β (Aβ) aggregation is involved in the elevation of oxidative stress, contributing to mitochondrial dysfunction and lipid peroxidation. In the present study, human placenta amniotic membrane-derived mesenchymal stem cells (hAMMSCs) were intravenously injected into C57BL/6J-APP transgenic mice. hAMMSCs significantly ameliorated spatial learning and memory function, and were associated with a decreased amount of amyloid plaques of the brain. The correlation of oxidative stress with Aβ levels was lower in the hAMMSCs-injected group than in the phosphate-buffered saline (PBS)-injected group, as indicated by the increased level of antioxidative enzymes and the decreased level of lipid peroxidation product. The glutathione (GSH) level and ratio of GSH to glutathione disulfide were higher in the hAMMSC group than in the PBS group. The superoxide dismutase activity and malonaldehyde level were improved significantly as the level of Aβ decreased, but there was no such trend in the PBS group. As a result, our findings represent evidence that hAMMSC treatment might improve the pathology of AD and memory function through the regulation of oxidative stress.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1877-1883 |
| Number of pages | 7 |
| Journal | Oncology Letters |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2016 |
| Externally published | Yes |
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Keywords
- Alzheimer’s disease
- Amyloid-β deposition
- Human placenta amniotic membrane-derived mesenchymal stem cells
- Oxidative stress
- Spatial memory function
- Transgenic mice
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Therapeutic potential of human amniotic membrane-derived mesenchymal stem cells in APP transgenic mice. / Jiao, Hongliang; Shi, Ke; Zhang, Weijie; Yang, Liang; Yang, Lu; Guan, Fangxia; Yang, Bo.
In: Oncology Letters, Vol. 12, No. 3, 01.09.2016, p. 1877-1883.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic potential of human amniotic membrane-derived mesenchymal stem cells in APP transgenic mice
AU - Jiao, Hongliang
AU - Shi, Ke
AU - Zhang, Weijie
AU - Yang, Liang
AU - Yang, Lu
AU - Guan, Fangxia
AU - Yang, Bo
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Growing evidence indicates that the presence of extensive oxidative stress plays an essential role in the initiation and progression of Alzheimer’s disease (AD). Amyloid-β (Aβ) aggregation is involved in the elevation of oxidative stress, contributing to mitochondrial dysfunction and lipid peroxidation. In the present study, human placenta amniotic membrane-derived mesenchymal stem cells (hAMMSCs) were intravenously injected into C57BL/6J-APP transgenic mice. hAMMSCs significantly ameliorated spatial learning and memory function, and were associated with a decreased amount of amyloid plaques of the brain. The correlation of oxidative stress with Aβ levels was lower in the hAMMSCs-injected group than in the phosphate-buffered saline (PBS)-injected group, as indicated by the increased level of antioxidative enzymes and the decreased level of lipid peroxidation product. The glutathione (GSH) level and ratio of GSH to glutathione disulfide were higher in the hAMMSC group than in the PBS group. The superoxide dismutase activity and malonaldehyde level were improved significantly as the level of Aβ decreased, but there was no such trend in the PBS group. As a result, our findings represent evidence that hAMMSC treatment might improve the pathology of AD and memory function through the regulation of oxidative stress.
AB - Growing evidence indicates that the presence of extensive oxidative stress plays an essential role in the initiation and progression of Alzheimer’s disease (AD). Amyloid-β (Aβ) aggregation is involved in the elevation of oxidative stress, contributing to mitochondrial dysfunction and lipid peroxidation. In the present study, human placenta amniotic membrane-derived mesenchymal stem cells (hAMMSCs) were intravenously injected into C57BL/6J-APP transgenic mice. hAMMSCs significantly ameliorated spatial learning and memory function, and were associated with a decreased amount of amyloid plaques of the brain. The correlation of oxidative stress with Aβ levels was lower in the hAMMSCs-injected group than in the phosphate-buffered saline (PBS)-injected group, as indicated by the increased level of antioxidative enzymes and the decreased level of lipid peroxidation product. The glutathione (GSH) level and ratio of GSH to glutathione disulfide were higher in the hAMMSC group than in the PBS group. The superoxide dismutase activity and malonaldehyde level were improved significantly as the level of Aβ decreased, but there was no such trend in the PBS group. As a result, our findings represent evidence that hAMMSC treatment might improve the pathology of AD and memory function through the regulation of oxidative stress.
KW - Alzheimer’s disease
KW - Amyloid-β deposition
KW - Human placenta amniotic membrane-derived mesenchymal stem cells
KW - Oxidative stress
KW - Spatial memory function
KW - Transgenic mice
UR - http://www.scopus.com/inward/record.url?scp=84979656102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84979656102&partnerID=8YFLogxK
U2 - 10.3892/ol.2016.4857
DO - 10.3892/ol.2016.4857
M3 - Article
AN - SCOPUS:84979656102
VL - 12
SP - 1877
EP - 1883
JO - Oncology Letters
JF - Oncology Letters
SN - 1792-1074
IS - 3
ER -