Therapeutic potential of hepatocyte transplantation

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Liver repopulation with transplanted cells offers unique opportunities for treating a variety of diseases and for studies of fundamental mechanisms in cell biology. Our understanding of the basis of liver repopulation has come from studies of transplanted cells in animal models. A variety of studies established that transplanted hepatocytes as well as stem/progenitor cells survive, engraft, and function in the liver. Transplanted cells survive life-long, although cells do not proliferate in the normal liver. On the other hand, the liver is repopulated extensively when diseases or other injuries afflict native hepatocytes but spare transplanted cells. The identification of ways to repopulate the liver with transplanted cells has greatly reinvigorated the field of liver cell therapy. The confluence of insights in stem/progenitor cells, transplantation immunology, cryobiology, and liver repopulation in specific models of human diseases indicates that the field of liver cell therapy will begin to reap the promised fruit in the near future.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume13
Issue number6
DOIs
StatePublished - Jan 1 2002

Keywords

  • Hepatocytes
  • Liver repopulation
  • Transplanted cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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