Therapeutic potential of hepatocyte transplantation

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Liver repopulation with transplanted cells offers unique opportunities for treating a variety of diseases and for studies of fundamental mechanisms in cell biology. Our understanding of the basis of liver repopulation has come from studies of transplanted cells in animal models. A variety of studies established that transplanted hepatocytes as well as stem/progenitor cells survive, engraft, and function in the liver. Transplanted cells survive life-long, although cells do not proliferate in the normal liver. On the other hand, the liver is repopulated extensively when diseases or other injuries afflict native hepatocytes but spare transplanted cells. The identification of ways to repopulate the liver with transplanted cells has greatly reinvigorated the field of liver cell therapy. The confluence of insights in stem/progenitor cells, transplantation immunology, cryobiology, and liver repopulation in specific models of human diseases indicates that the field of liver cell therapy will begin to reap the promised fruit in the near future.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume13
Issue number6
DOIs
StatePublished - 2002

Fingerprint

Hepatocytes
Transplantation
Liver
Stem Cells
Therapeutics
Cell- and Tissue-Based Therapy
Transplantation Immunology
Stem Cell Transplantation
Cell Biology
Fruit
Animal Models
Wounds and Injuries

Keywords

  • Hepatocytes
  • Liver repopulation
  • Transplanted cells

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Therapeutic potential of hepatocyte transplantation. / Gupta, Sanjeev; Roy-Chowdhury, Jayanta.

In: Seminars in Cell and Developmental Biology, Vol. 13, No. 6, 2002, p. 439-446.

Research output: Contribution to journalArticle

@article{0e0ea1993e7d466689ae0a004b9e64ce,
title = "Therapeutic potential of hepatocyte transplantation",
abstract = "Liver repopulation with transplanted cells offers unique opportunities for treating a variety of diseases and for studies of fundamental mechanisms in cell biology. Our understanding of the basis of liver repopulation has come from studies of transplanted cells in animal models. A variety of studies established that transplanted hepatocytes as well as stem/progenitor cells survive, engraft, and function in the liver. Transplanted cells survive life-long, although cells do not proliferate in the normal liver. On the other hand, the liver is repopulated extensively when diseases or other injuries afflict native hepatocytes but spare transplanted cells. The identification of ways to repopulate the liver with transplanted cells has greatly reinvigorated the field of liver cell therapy. The confluence of insights in stem/progenitor cells, transplantation immunology, cryobiology, and liver repopulation in specific models of human diseases indicates that the field of liver cell therapy will begin to reap the promised fruit in the near future.",
keywords = "Hepatocytes, Liver repopulation, Transplanted cells",
author = "Sanjeev Gupta and Jayanta Roy-Chowdhury",
year = "2002",
doi = "10.1016/S1084952102001325",
language = "English (US)",
volume = "13",
pages = "439--446",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - Therapeutic potential of hepatocyte transplantation

AU - Gupta, Sanjeev

AU - Roy-Chowdhury, Jayanta

PY - 2002

Y1 - 2002

N2 - Liver repopulation with transplanted cells offers unique opportunities for treating a variety of diseases and for studies of fundamental mechanisms in cell biology. Our understanding of the basis of liver repopulation has come from studies of transplanted cells in animal models. A variety of studies established that transplanted hepatocytes as well as stem/progenitor cells survive, engraft, and function in the liver. Transplanted cells survive life-long, although cells do not proliferate in the normal liver. On the other hand, the liver is repopulated extensively when diseases or other injuries afflict native hepatocytes but spare transplanted cells. The identification of ways to repopulate the liver with transplanted cells has greatly reinvigorated the field of liver cell therapy. The confluence of insights in stem/progenitor cells, transplantation immunology, cryobiology, and liver repopulation in specific models of human diseases indicates that the field of liver cell therapy will begin to reap the promised fruit in the near future.

AB - Liver repopulation with transplanted cells offers unique opportunities for treating a variety of diseases and for studies of fundamental mechanisms in cell biology. Our understanding of the basis of liver repopulation has come from studies of transplanted cells in animal models. A variety of studies established that transplanted hepatocytes as well as stem/progenitor cells survive, engraft, and function in the liver. Transplanted cells survive life-long, although cells do not proliferate in the normal liver. On the other hand, the liver is repopulated extensively when diseases or other injuries afflict native hepatocytes but spare transplanted cells. The identification of ways to repopulate the liver with transplanted cells has greatly reinvigorated the field of liver cell therapy. The confluence of insights in stem/progenitor cells, transplantation immunology, cryobiology, and liver repopulation in specific models of human diseases indicates that the field of liver cell therapy will begin to reap the promised fruit in the near future.

KW - Hepatocytes

KW - Liver repopulation

KW - Transplanted cells

UR - http://www.scopus.com/inward/record.url?scp=0036920161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036920161&partnerID=8YFLogxK

U2 - 10.1016/S1084952102001325

DO - 10.1016/S1084952102001325

M3 - Article

C2 - 12468245

AN - SCOPUS:0036920161

VL - 13

SP - 439

EP - 446

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 6

ER -