TY - JOUR
T1 - Therapeutic potential of hepatocyte transplantation
AU - Gupta, Sanjeev
AU - Roy Chowdhury, Jayanta
N1 - Funding Information:
This work was supported in part by NIH Grants R01 DK46952, R01 DK46057, P33DK41296, and P30 CA13330, and MO1 RR12248. The author gratefully acknowledges the contributions of his colleagues in many studies cited here.
PY - 2002
Y1 - 2002
N2 - Liver repopulation with transplanted cells offers unique opportunities for treating a variety of diseases and for studies of fundamental mechanisms in cell biology. Our understanding of the basis of liver repopulation has come from studies of transplanted cells in animal models. A variety of studies established that transplanted hepatocytes as well as stem/progenitor cells survive, engraft, and function in the liver. Transplanted cells survive life-long, although cells do not proliferate in the normal liver. On the other hand, the liver is repopulated extensively when diseases or other injuries afflict native hepatocytes but spare transplanted cells. The identification of ways to repopulate the liver with transplanted cells has greatly reinvigorated the field of liver cell therapy. The confluence of insights in stem/progenitor cells, transplantation immunology, cryobiology, and liver repopulation in specific models of human diseases indicates that the field of liver cell therapy will begin to reap the promised fruit in the near future.
AB - Liver repopulation with transplanted cells offers unique opportunities for treating a variety of diseases and for studies of fundamental mechanisms in cell biology. Our understanding of the basis of liver repopulation has come from studies of transplanted cells in animal models. A variety of studies established that transplanted hepatocytes as well as stem/progenitor cells survive, engraft, and function in the liver. Transplanted cells survive life-long, although cells do not proliferate in the normal liver. On the other hand, the liver is repopulated extensively when diseases or other injuries afflict native hepatocytes but spare transplanted cells. The identification of ways to repopulate the liver with transplanted cells has greatly reinvigorated the field of liver cell therapy. The confluence of insights in stem/progenitor cells, transplantation immunology, cryobiology, and liver repopulation in specific models of human diseases indicates that the field of liver cell therapy will begin to reap the promised fruit in the near future.
KW - Hepatocytes
KW - Liver repopulation
KW - Transplanted cells
UR - http://www.scopus.com/inward/record.url?scp=0036920161&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036920161&partnerID=8YFLogxK
U2 - 10.1016/S1084952102001325
DO - 10.1016/S1084952102001325
M3 - Review article
C2 - 12468245
AN - SCOPUS:0036920161
SN - 1084-9521
VL - 13
SP - 439
EP - 446
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
IS - 6
ER -
