Therapeutic potential of hematopoietic cells derived from pluripotent stem cells.

Research output: Contribution to journalArticle

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Abstract

Several challenges must be overcome before hematopoietic cells derived from pluripotent stem cells (PSCs) can be tested in the clinics. Pre-existing genetic mutations in somatic cells are a major concern for the production of iPSCs (induced pluripotent stem cells). This raises the question of what is the best somatic cell source to reprogram into iPSCs. Adult stem cells such as germ cell precursors and hematopoietic stem cells (HSCs) which are believed to be protected from somatic mutation accumulation are good candidates. Three gene editing methods have now been developed for human cells. Careful comparison of these methods is needed to determine the most appropriate for clinical applications. Differentiation of PSCs generally recapitulates early development. Therefore, cells produced from PSCs have an embryonic phenotype. Because transplantable HSCs and red blood cells expressing adult hemoglobin arise late in development, long after gastrulation, they have been difficult to produce from PSCs. The most difficult challenge is perhaps the development of methods to produce cells with an adult phenotype. Interestingly, recent reports suggest that primitive hematopoietic cells might make important contributions to adult hematopoiesis. Production of primitive hematopoietic cells might therefore have clinical applications.

Original languageEnglish (US)
Pages (from-to)1099-1102
Number of pages4
JournalExpert Opinion on Biological Therapy
Volume13
Issue number8
StatePublished - Aug 2013

Fingerprint

Pluripotent Stem Cells
Stem cells
Induced Pluripotent Stem Cells
Therapeutics
Hematopoietic Stem Cells
Cells
Phenotype
Gastrulation
Adult Stem Cells
Hematopoiesis
Germ Cells
Hemoglobins
Erythrocytes
Blood
Genes
Mutation

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery
  • Medicine(all)

Cite this

Therapeutic potential of hematopoietic cells derived from pluripotent stem cells. / Bouhassira, Eric E.

In: Expert Opinion on Biological Therapy, Vol. 13, No. 8, 08.2013, p. 1099-1102.

Research output: Contribution to journalArticle

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