Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection

Joydeep Ghosh, Vivek Swarup, Amit Saxena, Sulagna Das, Abhijit Hazra, Priyankar Paira, Sukdeb Banerjee, Nirup B. Mondal, Anirban Basu

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16 Scopus citations

Abstract

2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P < 0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Volume32
Issue number4
DOIs
Publication statusPublished - Oct 1 2008
Externally publishedYes

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Keywords

  • Anilidoquinoline
  • Apoptosis
  • Japanese encephalitis virus
  • Neuron
  • TUNEL

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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