Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection

Joydeep Ghosh, Vivek Swarup, Amit Saxena, Sulagna Das, Abhijit Hazra, Priyankar Paira, Sukdeb Banerjee, Nirup B. Mondal, Anirban Basu

Research output: Contribution to journalArticle

16 Scopus citations


2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P < 0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Issue number4
Publication statusPublished - Oct 1 2008
Externally publishedYes



  • Anilidoquinoline
  • Apoptosis
  • Japanese encephalitis virus
  • Neuron

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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