Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection

Joydeep Ghosh; Vivek Swarup; Amit Saxena; Sulagna Das; Abhijit Hazra; Priyankar Paira; Sukdeb Banerjee; Nirup B. Mondal; Anirban Basu

doi:10.1016/j.ijantimicag.2008.05.001

Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection

Joydeep Ghosh, Vivek Swarup, Amit Saxena, Sulagna Das, Abhijit Hazra, Priyankar Paira, Sukdeb Banerjee, Nirup B. Mondal, Anirban Basu

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P < 0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.

Original language	English (US)
Pages (from-to)	349-354
Number of pages	6
Journal	International Journal of Antimicrobial Agents
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.ijantimicag.2008.05.001
State	Published - Oct 2008
Externally published	Yes

Keywords

Anilidoquinoline
Apoptosis
Japanese encephalitis virus
Neuron
TUNEL

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijantimicag.2008.05.001

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Ghosh, J., Swarup, V., Saxena, A., Das, S., Hazra, A., Paira, P., Banerjee, S., Mondal, N. B., & Basu, A. (2008). Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection. International Journal of Antimicrobial Agents, 32(4), 349-354. https://doi.org/10.1016/j.ijantimicag.2008.05.001

Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection. / Ghosh, Joydeep; Swarup, Vivek; Saxena, Amit et al.
In: International Journal of Antimicrobial Agents, Vol. 32, No. 4, 10.2008, p. 349-354.

Research output: Contribution to journal › Article › peer-review

Ghosh, J, Swarup, V, Saxena, A, Das, S, Hazra, A, Paira, P, Banerjee, S, Mondal, NB & Basu, A 2008, 'Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection', International Journal of Antimicrobial Agents, vol. 32, no. 4, pp. 349-354. https://doi.org/10.1016/j.ijantimicag.2008.05.001

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abstract = "2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P < 0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.",

keywords = "Anilidoquinoline, Apoptosis, Japanese encephalitis virus, Neuron, TUNEL",

author = "Joydeep Ghosh and Vivek Swarup and Amit Saxena and Sulagna Das and Abhijit Hazra and Priyankar Paira and Sukdeb Banerjee and Mondal, {Nirup B.} and Anirban Basu",

note = "Funding Information: Funding: This work was supported by grant nos. BT/PR/5799/MED/14/698/2005 and BT/PR/8682/MED/14/1275/2007 from the Department of Biotechnology, Government of India, to AB. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.ijantimicag.2008.05.001",

language = "English (US)",

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AU - Paira, Priyankar

AU - Banerjee, Sukdeb

AU - Mondal, Nirup B.

AU - Basu, Anirban

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AB - 2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P < 0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.

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KW - Neuron

KW - TUNEL

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Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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