Therapeutic applications of low-molecular-weight thiols and selenocompounds

Pablo A. Nogara, Cláudia S. Oliveira, Meire E. Pereira, Marco Bortoli, Laura Orian, Michael Aschner, João B.T. Rocha

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses the pharmacological exploitation of low-molecular-weight thiol-containing molecules (LMW-SH) and a few selenocompounds with potential therapeutic use. Although the number of organoselenium molecules is huge, few of them have been tested in clinical trials. Most of the studies involving low-molecular-weight selenium-containing molecules (LMW-Se) are related to their modulatory effects on inflammation and redox balance. Nevertheless, the absence of studies demonstrating the speciation of selenium is a bottleneck. The LMW-SH molecules are essential to cellular milieu redox homeostasis. Considering that several diseases and/or toxicants can negatively modulate the redox balance, the use of endogenous and synthetic LMW-SH as therapeutic agents can be a promising strategy to treat pathologies associated with oxidative stress.

Original languageEnglish (US)
Title of host publicationRedox Chemistry and Biology of Thiols
PublisherElsevier
Pages643-677
Number of pages35
ISBN (Electronic)9780323902199
ISBN (Print)9780323915663
DOIs
StatePublished - Jan 1 2022

Keywords

  • NRF2
  • Reactivity
  • Redox balance
  • Selenium
  • Selenol
  • Sulfur
  • Thiol

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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