The Wnt signaling pathway

Implications for therapy in osteosarcoma

Peter McQueen, Samia Ghaffar, Yi Guo, Elyssa M. Rubin, Xiaolin Zi, Bang H. Hoang

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Osteosarcoma is the most common primary bone malignancy, with a high propensity for local invasion, early metastasis and relapse. While the molecular mechanisms behind osteosarcoma development and metastasis have not yet been fully elucidated, research has highlighted an important role for Wnt signaling. Several Wnt ligands, receptors and coreceptors are highly expressed in osteosarcoma cell lines, while Wnt inhibitors are downregulated. As a result, research has begun to identify mechanisms with which to inhibit Wnt signaling. The use of Wnt pathway inhibitors and the targeting of c-Met, a Wnt regulated proto-oncogene, may be two possible mechanisms for treatment of osteosarcoma. In addition, as the Wnt signaling pathway is a regulator of stem cells, reagents that function as Wnt inhibitors are currently under investigation as inhibitors of cancer stem cell proliferation. Research involving the Wnt signaling pathway and cancer stem cells holds promise for novel treatment options in the future.

Original languageEnglish (US)
Pages (from-to)1223-1232
Number of pages10
JournalExpert Review of Anticancer Therapy
Volume11
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Wnt Signaling Pathway
Osteosarcoma
Neoplastic Stem Cells
Wnt Receptors
Research
Neoplasm Metastasis
Proto-Oncogenes
Therapeutics
Stem Cells
Down-Regulation
Cell Proliferation
Ligands
Bone and Bones
Recurrence
Cell Line
Neoplasms

Keywords

  • c-Met
  • cancer stem cells
  • DKK3
  • Frzb
  • LRP5
  • osteosarcoma
  • WIF-1
  • Wnt signaling

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

Cite this

The Wnt signaling pathway : Implications for therapy in osteosarcoma. / McQueen, Peter; Ghaffar, Samia; Guo, Yi; Rubin, Elyssa M.; Zi, Xiaolin; Hoang, Bang H.

In: Expert Review of Anticancer Therapy, Vol. 11, No. 8, 08.2011, p. 1223-1232.

Research output: Contribution to journalArticle

McQueen, Peter ; Ghaffar, Samia ; Guo, Yi ; Rubin, Elyssa M. ; Zi, Xiaolin ; Hoang, Bang H. / The Wnt signaling pathway : Implications for therapy in osteosarcoma. In: Expert Review of Anticancer Therapy. 2011 ; Vol. 11, No. 8. pp. 1223-1232.
@article{5551010b485b4d0988a2e8f977943a3c,
title = "The Wnt signaling pathway: Implications for therapy in osteosarcoma",
abstract = "Osteosarcoma is the most common primary bone malignancy, with a high propensity for local invasion, early metastasis and relapse. While the molecular mechanisms behind osteosarcoma development and metastasis have not yet been fully elucidated, research has highlighted an important role for Wnt signaling. Several Wnt ligands, receptors and coreceptors are highly expressed in osteosarcoma cell lines, while Wnt inhibitors are downregulated. As a result, research has begun to identify mechanisms with which to inhibit Wnt signaling. The use of Wnt pathway inhibitors and the targeting of c-Met, a Wnt regulated proto-oncogene, may be two possible mechanisms for treatment of osteosarcoma. In addition, as the Wnt signaling pathway is a regulator of stem cells, reagents that function as Wnt inhibitors are currently under investigation as inhibitors of cancer stem cell proliferation. Research involving the Wnt signaling pathway and cancer stem cells holds promise for novel treatment options in the future.",
keywords = "c-Met, cancer stem cells, DKK3, Frzb, LRP5, osteosarcoma, WIF-1, Wnt signaling",
author = "Peter McQueen and Samia Ghaffar and Yi Guo and Rubin, {Elyssa M.} and Xiaolin Zi and Hoang, {Bang H.}",
year = "2011",
month = "8",
doi = "10.1586/era.11.94",
language = "English (US)",
volume = "11",
pages = "1223--1232",
journal = "Expert Review of Anticancer Therapy",
issn = "1473-7140",
publisher = "Expert Reviews Ltd.",
number = "8",

}

TY - JOUR

T1 - The Wnt signaling pathway

T2 - Implications for therapy in osteosarcoma

AU - McQueen, Peter

AU - Ghaffar, Samia

AU - Guo, Yi

AU - Rubin, Elyssa M.

AU - Zi, Xiaolin

AU - Hoang, Bang H.

PY - 2011/8

Y1 - 2011/8

N2 - Osteosarcoma is the most common primary bone malignancy, with a high propensity for local invasion, early metastasis and relapse. While the molecular mechanisms behind osteosarcoma development and metastasis have not yet been fully elucidated, research has highlighted an important role for Wnt signaling. Several Wnt ligands, receptors and coreceptors are highly expressed in osteosarcoma cell lines, while Wnt inhibitors are downregulated. As a result, research has begun to identify mechanisms with which to inhibit Wnt signaling. The use of Wnt pathway inhibitors and the targeting of c-Met, a Wnt regulated proto-oncogene, may be two possible mechanisms for treatment of osteosarcoma. In addition, as the Wnt signaling pathway is a regulator of stem cells, reagents that function as Wnt inhibitors are currently under investigation as inhibitors of cancer stem cell proliferation. Research involving the Wnt signaling pathway and cancer stem cells holds promise for novel treatment options in the future.

AB - Osteosarcoma is the most common primary bone malignancy, with a high propensity for local invasion, early metastasis and relapse. While the molecular mechanisms behind osteosarcoma development and metastasis have not yet been fully elucidated, research has highlighted an important role for Wnt signaling. Several Wnt ligands, receptors and coreceptors are highly expressed in osteosarcoma cell lines, while Wnt inhibitors are downregulated. As a result, research has begun to identify mechanisms with which to inhibit Wnt signaling. The use of Wnt pathway inhibitors and the targeting of c-Met, a Wnt regulated proto-oncogene, may be two possible mechanisms for treatment of osteosarcoma. In addition, as the Wnt signaling pathway is a regulator of stem cells, reagents that function as Wnt inhibitors are currently under investigation as inhibitors of cancer stem cell proliferation. Research involving the Wnt signaling pathway and cancer stem cells holds promise for novel treatment options in the future.

KW - c-Met

KW - cancer stem cells

KW - DKK3

KW - Frzb

KW - LRP5

KW - osteosarcoma

KW - WIF-1

KW - Wnt signaling

UR - http://www.scopus.com/inward/record.url?scp=80052324818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052324818&partnerID=8YFLogxK

U2 - 10.1586/era.11.94

DO - 10.1586/era.11.94

M3 - Article

VL - 11

SP - 1223

EP - 1232

JO - Expert Review of Anticancer Therapy

JF - Expert Review of Anticancer Therapy

SN - 1473-7140

IS - 8

ER -