TY - JOUR
T1 - The vitamin D metabolite ratio (VMR) as a predictor of functional biomarkers of bone health
AU - Aloia, John
AU - Fazzari, Melissa
AU - Shieh, Albert
AU - Dhaliwal, Ruban
AU - Mikhail, Mageda
AU - Hoofnagle, Andrew N.
AU - Ragolia, Lou
N1 - Funding Information:
This work was supported by National Institute for Health - Grant RO1-AG032440?01A2.
Publisher Copyright:
© 2017 John Wiley & Sons Ltd
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Context: The vitamin D metabolite ratio (VMR) (serum 24,25(OH)2D3/25(OH)D3) has been proposed as a biomarker of vitamin D sufficiency to replace serum 25(OH)D. Objective: To examine the relationships of 24,25(OH)2D3 and VMR to functional biomarkers of bone health following vitamin D supplementation. Setting: An ambulatory research centre. Design: Serum from a previous research study of dose response of PTH, calcium absorption and bone turnover to vitamin D supplementation was analysed for vitamin D metabolites (25(OH)D, 24,25(OH)2D3). Outcome: The relationship of serum 24,25(OH)2D3 and VMR to calcium absorption, PTH and bone turnover markers was examined. Results: Although there were strong correlations of serum 25(OH)D with 24,25(OH)2D3 and free 25(OH)D, its correlation with VMR was lower. After vitamin D supplementation, the change in 25(OH)D, 24,25(OH)2D3 and VMR was associated with the change in calcium absorption, PTH and CTX. The correlation of the change in PTH with the change in metabolites was the lowest for VMR. Moreover, estimated dose response for standardized values of vitamin D metabolites showed a beta-coefficient for VMR that was significantly less in magnitude compared to other metabolites. Conclusion: Serum 24,25(OH)2D3 is closely associated with the dose response of serum 25(OH)D to vitamin D supplementation. However, the VMR does not appear to be equivalent to either of these metabolites in its response to increasing vitamin D intake or its association with PTH. It is unlikely that VMR will replace 25(OH)D as a biomarker for vitamin D sufficiency.
AB - Context: The vitamin D metabolite ratio (VMR) (serum 24,25(OH)2D3/25(OH)D3) has been proposed as a biomarker of vitamin D sufficiency to replace serum 25(OH)D. Objective: To examine the relationships of 24,25(OH)2D3 and VMR to functional biomarkers of bone health following vitamin D supplementation. Setting: An ambulatory research centre. Design: Serum from a previous research study of dose response of PTH, calcium absorption and bone turnover to vitamin D supplementation was analysed for vitamin D metabolites (25(OH)D, 24,25(OH)2D3). Outcome: The relationship of serum 24,25(OH)2D3 and VMR to calcium absorption, PTH and bone turnover markers was examined. Results: Although there were strong correlations of serum 25(OH)D with 24,25(OH)2D3 and free 25(OH)D, its correlation with VMR was lower. After vitamin D supplementation, the change in 25(OH)D, 24,25(OH)2D3 and VMR was associated with the change in calcium absorption, PTH and CTX. The correlation of the change in PTH with the change in metabolites was the lowest for VMR. Moreover, estimated dose response for standardized values of vitamin D metabolites showed a beta-coefficient for VMR that was significantly less in magnitude compared to other metabolites. Conclusion: Serum 24,25(OH)2D3 is closely associated with the dose response of serum 25(OH)D to vitamin D supplementation. However, the VMR does not appear to be equivalent to either of these metabolites in its response to increasing vitamin D intake or its association with PTH. It is unlikely that VMR will replace 25(OH)D as a biomarker for vitamin D sufficiency.
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U2 - 10.1111/cen.13319
DO - 10.1111/cen.13319
M3 - Article
C2 - 28251655
AN - SCOPUS:85017233599
VL - 86
SP - 674
EP - 679
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 5
ER -