The visceral fat compartment is independently associated with changes in urine constituent excretion in a stone forming population

Ethan B. Fram, Ilir Agalliu, Joseph DiVito, David M. Hoenig, Joshua M. Stern

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The objective of this study was to identify the independent effect of visceral fat on urine constituent excretion in a stone forming population. Using a database of 382 kidney stone patients with available visceral fat quantification, we created multiple linear regression models predicting changes in urinary solutes based on visceral fat area and body mass-index, divided by gender. Chi-square tests were used to compare stone composition by body mass-index and visceral fat area. Visceral fat predicts increases in urinary creatinine, sodium, and volume in men, but only urinary phosphate in women. In women, total body mass-index does not appear to modify this effect, but in men it is more pronounced in overweight patients for creatinine and volume only. Elevated visceral fat is associated with increased probability of uric acid stone composition. Different fat compartments likely effect urine composition in different ways. This effect appears to be different in men and women. Understanding and quantifying the effects of different fat compartments is probably important to understanding the metabolism of urolithiasis.

Original languageEnglish (US)
Article number3
Pages (from-to)213-220
Number of pages8
JournalUrolithiasis
Volume43
Issue number3
DOIs
StatePublished - Jun 22 2015

Keywords

  • Computed tomography imaging
  • Intra-abdominal fat
  • Kidney calculi
  • Ureteroscopy
  • Urine specimen collection

ASJC Scopus subject areas

  • Urology

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