The vessel wall and its interactions

Denisa D. Wagner; Paul S. Frenette

doi:10.1182/blood-2008-01-078204

The vessel wall and its interactions

Denisa D. Wagner, Paul S. Frenette

Research output: Contribution to journal › Article › peer-review

209 Scopus citations

Abstract

Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field.

Original language	English (US)
Pages (from-to)	5271-5281
Number of pages	11
Journal	Blood
Volume	111
Issue number	11
DOIs	https://doi.org/10.1182/blood-2008-01-078204
State	Published - Jun 1 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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