Abstract
Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5271-5281 |
| Number of pages | 11 |
| Journal | Blood |
| Volume | 111 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 1 2008 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Hematology
- Biochemistry
- Cell Biology
- Immunology
Cite this
The vessel wall and its interactions. / Wagner, Denisa D.; Frenette, Paul S.
In: Blood, Vol. 111, No. 11, 01.06.2008, p. 5271-5281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The vessel wall and its interactions
AU - Wagner, Denisa D.
AU - Frenette, Paul S.
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field.
AB - Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field.
UR - http://www.scopus.com/inward/record.url?scp=45949101608&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45949101608&partnerID=8YFLogxK
U2 - 10.1182/blood-2008-01-078204
DO - 10.1182/blood-2008-01-078204
M3 - Article
VL - 111
SP - 5271
EP - 5281
JO - Blood
JF - Blood
SN - 0006-4971
IS - 11
ER -