The vessel wall and its interactions

Denisa D. Wagner, Paul S. Frenette

Research output: Contribution to journalArticle

199 Scopus citations

Abstract

Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field.

Original languageEnglish (US)
Pages (from-to)5271-5281
Number of pages11
JournalBlood
Volume111
Issue number11
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this