The ventral pallidum area is involved in the acquisition but not expression of the amphetamine conditioned place preference

Noboru Hiroi, Norman M. White

Research output: Contribution to journalArticle

54 Scopus citations


The present study examined the roles of the ventral pallidum area, one output system of the nucleus accumbens, in the acquisition and expression of the amphetamine conditioned place preference (CPP). Pre-conditioning NMDA lesions of the ventral pallidum area completely abolished the acquisition of the CPP. By contrast, post-conditioning NMDA lesions of the same area had no effect on the expression of the CPP. These results suggest that the ventral pallidum area mediates some process that involves the primary, but not conditioned rewarding effects of amphetamine.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - Jun 25 1993



  • Addiction
  • Amphetamine
  • Conditioned place preference
  • Reward
  • Stimulant
  • Ventral pallidum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this