The vasculature in chagas disease

Cibele M. Prado, Linda A. Jelicks, Louis M. Weiss, Stephen M. Factor, Herbert B. Tanowitz, Marcos A. Rossi

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

The cardiovascular manifestations of Chagas disease are well known. However, the contribution of the vasculature and specifically the microvasculature has received little attention. This chapter reviews the evidence supporting the notion that alterations in the microvasculature especially in the heart contribute to the pathogenesis of chagasic cardiomyopathy. These data may also be important in understanding the contributions of the microvasculature in the aetiologies of other cardiomyopathies. The role of endothelin-1 and of thromboxane A 2 vascular spasm and platelet aggregation is also discussed. Further, these observations may provide target(s) for intervention.

Original languageEnglish (US)
Title of host publicationAdvances in Parasitology
PublisherAcademic Press
Pages83-99
Number of pages17
DOIs
StatePublished - 2011

Publication series

NameAdvances in Parasitology
Volume76
ISSN (Print)0065-308X

Keywords

  • Chagas disease
  • Chagas heart disease
  • Cytokines
  • Endothelin
  • Inflamamtion
  • Thromboxane
  • Trypanosoma cruzi
  • Vasculature
  • Vasculitis

ASJC Scopus subject areas

  • Parasitology

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