The vasculature in chagas disease

Cibele M. Prado, Linda A. Jelicks, Louis M. Weiss, Stephen M. Factor, Herbert B. Tanowitz, Marcos A. Rossi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The cardiovascular manifestations of Chagas disease are well known. However, the contribution of the vasculature and specifically the microvasculature has received little attention. This chapter reviews the evidence supporting the notion that alterations in the microvasculature especially in the heart contribute to the pathogenesis of chagasic cardiomyopathy. These data may also be important in understanding the contributions of the microvasculature in the aetiologies of other cardiomyopathies. The role of endothelin-1 and of thromboxane A 2 vascular spasm and platelet aggregation is also discussed. Further, these observations may provide target(s) for intervention.

Original languageEnglish (US)
Pages (from-to)83-99
Number of pages17
JournalAdvances in Parasitology
Volume76
DOIs
StatePublished - 2011

Fingerprint

Chagas Disease
Microvessels
Cardiomyopathies
Thromboxanes
Spasm
Endothelin-1
Platelet Aggregation
varespladib methyl
Blood Vessels

Keywords

  • Chagas disease
  • Chagas heart disease
  • Cytokines
  • Endothelin
  • Inflamamtion
  • Thromboxane
  • Trypanosoma cruzi
  • Vasculature
  • Vasculitis

ASJC Scopus subject areas

  • Parasitology

Cite this

Prado, C. M., Jelicks, L. A., Weiss, L. M., Factor, S. M., Tanowitz, H. B., & Rossi, M. A. (2011). The vasculature in chagas disease. Advances in Parasitology, 76, 83-99. https://doi.org/10.1016/B978-0-12-385895-5.00004-9

The vasculature in chagas disease. / Prado, Cibele M.; Jelicks, Linda A.; Weiss, Louis M.; Factor, Stephen M.; Tanowitz, Herbert B.; Rossi, Marcos A.

In: Advances in Parasitology, Vol. 76, 2011, p. 83-99.

Research output: Contribution to journalArticle

Prado, CM, Jelicks, LA, Weiss, LM, Factor, SM, Tanowitz, HB & Rossi, MA 2011, 'The vasculature in chagas disease', Advances in Parasitology, vol. 76, pp. 83-99. https://doi.org/10.1016/B978-0-12-385895-5.00004-9
Prado, Cibele M. ; Jelicks, Linda A. ; Weiss, Louis M. ; Factor, Stephen M. ; Tanowitz, Herbert B. ; Rossi, Marcos A. / The vasculature in chagas disease. In: Advances in Parasitology. 2011 ; Vol. 76. pp. 83-99.
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