@inbook{8db2626aff254d83a5a96df0f18a013b,
title = "The vasculature in chagas disease",
abstract = " The cardiovascular manifestations of Chagas disease are well known. However, the contribution of the vasculature and specifically the microvasculature has received little attention. This chapter reviews the evidence supporting the notion that alterations in the microvasculature especially in the heart contribute to the pathogenesis of chagasic cardiomyopathy. These data may also be important in understanding the contributions of the microvasculature in the aetiologies of other cardiomyopathies. The role of endothelin-1 and of thromboxane A 2 vascular spasm and platelet aggregation is also discussed. Further, these observations may provide target(s) for intervention.",
keywords = "Chagas disease, Chagas heart disease, Cytokines, Endothelin, Inflamamtion, Thromboxane, Trypanosoma cruzi, Vasculature, Vasculitis",
author = "Prado, {Cibele M.} and Jelicks, {Linda A.} and Weiss, {Louis M.} and Factor, {Stephen M.} and Tanowitz, {Herbert B.} and Rossi, {Marcos A.}",
note = "Funding Information: This work was supported by grants from the Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (M. A. R.; FAPESP 09/17787-8; 10/19216-5) and National Institutes of Health (NIH) Grants AI-076248 (H. B. T.) and CA-123334 (L. A. J.). C. M. P. was supported in part by a grant from the Fogarty International Center–NIH (D43-TW007129). M. A. R. is senior investigator of the Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq).",
year = "2011",
doi = "10.1016/B978-0-12-385895-5.00004-9",
language = "English (US)",
series = "Advances in Parasitology",
publisher = "Academic Press",
pages = "83--99",
booktitle = "Advances in Parasitology",
}
