The variability of stimulus thresholds in electrophysiologic cortical language mapping

Sonya G. Wang, Emad N. Eskandar, Ronan Kilbride, Keith H. Chiappa, William T. Curry, Ziv Williams, Mirela V. Simon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The aim of this study was to investigate the variability of electrical stimulation threshold in cortical language mapping in relationship to the lobar location of the mapped eloquent cortex and the distance between the latter and the location of the cortical lesion. A multivariate linear regression analysis was performed in a sample of 39 patients who underwent standardized successful language cortical mapping. Estimated stimulus threshold for temporal language cortex was 1.45 times higher than the estimated threshold for frontal language cortex, after adjusting for the other variables (P = 0.017). Stimulation of the mapped cortex in close proximity to the lesion or to the lesional edema increased the estimated threshold 2.6 or 1.8 times, respectively, compared with stimulation in other areas, after adjusting for the other variables (P < 0.0001, P = 0.0017). In concordance with prior findings, our results show that stimulus threshold in cortical language mapping is dependent on the lobar location of the mapped cortex. In addition, stimulus threshold is increased when the mapped cortex is in close proximity to the location of the lesion or perilesional edema.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalJournal of Clinical Neurophysiology
Volume28
Issue number2
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

Fingerprint

Language
Edema
Frontal Lobe
Temporal Lobe
Electric Stimulation
Linear Models
Regression Analysis

Keywords

  • Cortical excitability
  • Language cortical mapping
  • Lesion location
  • Stimulus thresholds

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

The variability of stimulus thresholds in electrophysiologic cortical language mapping. / Wang, Sonya G.; Eskandar, Emad N.; Kilbride, Ronan; Chiappa, Keith H.; Curry, William T.; Williams, Ziv; Simon, Mirela V.

In: Journal of Clinical Neurophysiology, Vol. 28, No. 2, 01.04.2011, p. 210-216.

Research output: Contribution to journalArticle

Wang, Sonya G. ; Eskandar, Emad N. ; Kilbride, Ronan ; Chiappa, Keith H. ; Curry, William T. ; Williams, Ziv ; Simon, Mirela V. / The variability of stimulus thresholds in electrophysiologic cortical language mapping. In: Journal of Clinical Neurophysiology. 2011 ; Vol. 28, No. 2. pp. 210-216.
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