The variability in prognostic values of right ventricular-to-left ventricular diameter ratios derived from different measurement methods on computed tomography pulmonary angiography: A patient outcome study

Kanako K. Kumamaru, Andetta R. Hunsaker, Nicole Wake, Michael T. Lu, Jason Signorelli, Arash Bedayat, Frank J. Rybicki

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: To evaluate variability in right ventricular-to-left ventricular (RV/LV) diameter ratios introduced by differences in measurement methods and the subsequent influence on the accuracy of predicting outcomes for patients with acute pulmonary embolism (PE). Materials and Methods: For 200 consecutive computed tomography pulmonary angiograms positive for acute PE, RV/LV diameter ratios were retrospectively measured using 3 different 4-chamber reformations and from axial images alone. The first 4-chamber reformation method (4ch-1) was a single oblique technique using LV morphology landmarks; the other 2 methods (4ch-2 and 4ch-3) were double oblique techniques that created an intermediate short-axis image to identify the maximum RV diameter but with different approaches to reach short-axis images. Interobserver variability was measured using 30 cases. Receiver-operating characteristic analysis compared the accuracy of predicting outcomes among the 4 measurements for PE-related death, and for death or the need for intensive therapies (composite outcome). Results: The difference in median RV/LV diameter ratios was insignificant among 4ch-2 (1.01), 4ch-3 (1.02), and axial (1.03) datasets, whereas that from 4ch-1 (0.93) was significantly lower (P<0.001). Correlation between observers was excellent for all 4 datasets (r=0.881 to 0.925). Compared with 4ch-1, the other 3 datasets equally achieved higher accuracy in predicting PE-related 30-day mortality (area under curve: 0.55 vs. 0.69 to 0.73, P=0.007 to 0.019) and a composite outcome (area under curve: 0.65 vs. 0.77 to 0.78, P=0.003 to 0.010). Conclusions: Double oblique 4-chamber reformation methods that use intermediate short-axis images to optimize RV size predict outcomes better in patients with acute PE than do single oblique methods using only LV landmarks; however, their accuracy is not superior to that from measurements based on axial images.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalJournal of Thoracic Imaging
Volume27
Issue number5
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

Pulmonary Embolism
Outcome Assessment (Health Care)
Lung
Area Under Curve
Observer Variation
ROC Curve
Computed Tomography Angiography
Angiography
Tomography
Mortality
Datasets
Therapeutics

Keywords

  • cardiovascular
  • computed tomography angiography
  • image processing
  • pulmonary embolism
  • variability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pulmonary and Respiratory Medicine

Cite this

The variability in prognostic values of right ventricular-to-left ventricular diameter ratios derived from different measurement methods on computed tomography pulmonary angiography : A patient outcome study. / Kumamaru, Kanako K.; Hunsaker, Andetta R.; Wake, Nicole; Lu, Michael T.; Signorelli, Jason; Bedayat, Arash; Rybicki, Frank J.

In: Journal of Thoracic Imaging, Vol. 27, No. 5, 01.09.2012, p. 331-336.

Research output: Contribution to journalArticle

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AU - Wake, Nicole

AU - Lu, Michael T.

AU - Signorelli, Jason

AU - Bedayat, Arash

AU - Rybicki, Frank J.

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AB - Purpose: To evaluate variability in right ventricular-to-left ventricular (RV/LV) diameter ratios introduced by differences in measurement methods and the subsequent influence on the accuracy of predicting outcomes for patients with acute pulmonary embolism (PE). Materials and Methods: For 200 consecutive computed tomography pulmonary angiograms positive for acute PE, RV/LV diameter ratios were retrospectively measured using 3 different 4-chamber reformations and from axial images alone. The first 4-chamber reformation method (4ch-1) was a single oblique technique using LV morphology landmarks; the other 2 methods (4ch-2 and 4ch-3) were double oblique techniques that created an intermediate short-axis image to identify the maximum RV diameter but with different approaches to reach short-axis images. Interobserver variability was measured using 30 cases. Receiver-operating characteristic analysis compared the accuracy of predicting outcomes among the 4 measurements for PE-related death, and for death or the need for intensive therapies (composite outcome). Results: The difference in median RV/LV diameter ratios was insignificant among 4ch-2 (1.01), 4ch-3 (1.02), and axial (1.03) datasets, whereas that from 4ch-1 (0.93) was significantly lower (P<0.001). Correlation between observers was excellent for all 4 datasets (r=0.881 to 0.925). Compared with 4ch-1, the other 3 datasets equally achieved higher accuracy in predicting PE-related 30-day mortality (area under curve: 0.55 vs. 0.69 to 0.73, P=0.007 to 0.019) and a composite outcome (area under curve: 0.65 vs. 0.77 to 0.78, P=0.003 to 0.010). Conclusions: Double oblique 4-chamber reformation methods that use intermediate short-axis images to optimize RV size predict outcomes better in patients with acute PE than do single oblique methods using only LV landmarks; however, their accuracy is not superior to that from measurements based on axial images.

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