@article{02b1cc9ecf6049c1b7a393a920ea3b16,
title = "The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study",
abstract = "In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher{\textquoteright}s aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.",
keywords = "HIV/AIDS, Intervention studies, Medication adherence assessment, Social desirability",
author = "Simoni, {Jane M.} and David Huh and Yan Wang and Wilson, {Ira B.} and Reynolds, {Nancy R.} and Remien, {Robert H.} and Kathy Goggin and Robert Gross and Rosen, {Marc I.} and Neil Schneiderman and Julia Arnsten and Golin, {Carol E.} and Erlen, {Judith A.} and Bangsberg, {David R.} and Honghu Liu",
note = "Funding Information: Acknowledgments This research was supported by the multi-site adherence collaboration in HIV (MACH14) grant R01MH078773 from the National Institute of Mental Health Office on AIDS. The original grants of individual participating studies are: R01DA11869, R01MH54907, R01NR04749, 2R01NR04749, R01MH068197, R01DA13826, K23MH01862, K08 MH01584, R01AI41413, R01MH61173, AI38858, AI069419, K02DA017277, R01DA15215, P01MH49548, R01MH58986, R01MH61695, CC99-SD003, CC02-SD-003 and R01DA015679. Additional support was provided by K24MH093243 and P30AI27757 (to Simoni) and by P30AI050410 (to Golin). We would like to thank all the individual patients who participated. The content of the paper is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions involved. Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media New York.",
year = "2014",
month = dec,
day = "1",
doi = "10.1007/s10461-014-0905-x",
language = "English (US)",
volume = "18",
pages = "2285--2290",
journal = "AIDS and Behavior",
issn = "1090-7165",
publisher = "Springer New York",
number = "12",
}
