The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism

Anathea C. Powell; H. Richard Alexander; James F. Pingpank; Seth M. Steinberg; Monica Skarulis; David L. Bartlett; Sunita Agarwal; Craig Cochran; Geoffrey Seidel; Douglas Fraker; Marybeth S. Hughes; Robert T. Jensen; Stephen J. Marx; Steven K. Libutti

doi:10.1016/j.surg.2008.08.031

The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism

Anathea C. Powell, H. Richard Alexander, James F. Pingpank, Seth M. Steinberg, Monica Skarulis, David L. Bartlett, Sunita Agarwal, Craig Cochran, Geoffrey Seidel, Douglas Fraker, Marybeth S. Hughes, Robert T. Jensen, Stephen J. Marx, Steven K. Libutti

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Background: Operation for multiple endocrine neoplasia (MEN)1-related hyperparathyroidism (HPT) includes a neck exploration with resection of 3.5 or 4 parathyroid glands and transcervical thymectomy (TCT). We reviewed our experience with initial operation for primary HPT to determine the outcome and utility of routine TCT. Methods: All patients with MEN1 who underwent initial neck exploration from 1993 to 2007 under an institutional review board-approved protocol were reviewed. Results: We identified 66 patients with initial operation for HPT in MEN1. In 34 patients, 4 glands were found; in 32 patients, <4 glands were found. In 2 of the 34 (6%) and 17 of the 32 (53%), intrathymic parathyroid tissue was found on permanent pathology. No thymic carcinoid tissue was found in any specimen. Conclusion: These data highlight the importance of performing TCT when <4 entopic parathyroid glands are found at first operation.

Original language	English (US)
Pages (from-to)	878-884
Number of pages	7
Journal	Surgery
Volume	144
Issue number	6
DOIs	https://doi.org/10.1016/j.surg.2008.08.031
State	Published - Dec 2008
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1016/j.surg.2008.08.031

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Powell, A. C., Alexander, H. R., Pingpank, J. F., Steinberg, S. M., Skarulis, M., Bartlett, D. L., Agarwal, S., Cochran, C., Seidel, G., Fraker, D., Hughes, M. S., Jensen, R. T., Marx, S. J., & Libutti, S. K. (2008). The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism. Surgery, 144(6), 878-884. https://doi.org/10.1016/j.surg.2008.08.031

Powell, AC, Alexander, HR, Pingpank, JF, Steinberg, SM, Skarulis, M, Bartlett, DL, Agarwal, S, Cochran, C, Seidel, G, Fraker, D, Hughes, MS, Jensen, RT, Marx, SJ & Libutti, SK 2008, 'The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism', Surgery, vol. 144, no. 6, pp. 878-884. https://doi.org/10.1016/j.surg.2008.08.031

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title = "The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism",

abstract = "Background: Operation for multiple endocrine neoplasia (MEN)1-related hyperparathyroidism (HPT) includes a neck exploration with resection of 3.5 or 4 parathyroid glands and transcervical thymectomy (TCT). We reviewed our experience with initial operation for primary HPT to determine the outcome and utility of routine TCT. Methods: All patients with MEN1 who underwent initial neck exploration from 1993 to 2007 under an institutional review board-approved protocol were reviewed. Results: We identified 66 patients with initial operation for HPT in MEN1. In 34 patients, 4 glands were found; in 32 patients, <4 glands were found. In 2 of the 34 (6%) and 17 of the 32 (53%), intrathymic parathyroid tissue was found on permanent pathology. No thymic carcinoid tissue was found in any specimen. Conclusion: These data highlight the importance of performing TCT when <4 entopic parathyroid glands are found at first operation.",

author = "Powell, {Anathea C.} and Alexander, {H. Richard} and Pingpank, {James F.} and Steinberg, {Seth M.} and Monica Skarulis and Bartlett, {David L.} and Sunita Agarwal and Craig Cochran and Geoffrey Seidel and Douglas Fraker and Hughes, {Marybeth S.} and Jensen, {Robert T.} and Marx, {Stephen J.} and Libutti, {Steven K.}",

year = "2008",

month = dec,

doi = "10.1016/j.surg.2008.08.031",

language = "English (US)",

volume = "144",

pages = "878--884",

journal = "Surgery",

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T1 - The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism

AU - Powell, Anathea C.

AU - Alexander, H. Richard

AU - Pingpank, James F.

AU - Steinberg, Seth M.

AU - Skarulis, Monica

AU - Bartlett, David L.

AU - Agarwal, Sunita

AU - Cochran, Craig

AU - Seidel, Geoffrey

AU - Fraker, Douglas

AU - Hughes, Marybeth S.

AU - Jensen, Robert T.

AU - Marx, Stephen J.

AU - Libutti, Steven K.

PY - 2008/12

Y1 - 2008/12

N2 - Background: Operation for multiple endocrine neoplasia (MEN)1-related hyperparathyroidism (HPT) includes a neck exploration with resection of 3.5 or 4 parathyroid glands and transcervical thymectomy (TCT). We reviewed our experience with initial operation for primary HPT to determine the outcome and utility of routine TCT. Methods: All patients with MEN1 who underwent initial neck exploration from 1993 to 2007 under an institutional review board-approved protocol were reviewed. Results: We identified 66 patients with initial operation for HPT in MEN1. In 34 patients, 4 glands were found; in 32 patients, <4 glands were found. In 2 of the 34 (6%) and 17 of the 32 (53%), intrathymic parathyroid tissue was found on permanent pathology. No thymic carcinoid tissue was found in any specimen. Conclusion: These data highlight the importance of performing TCT when <4 entopic parathyroid glands are found at first operation.

AB - Background: Operation for multiple endocrine neoplasia (MEN)1-related hyperparathyroidism (HPT) includes a neck exploration with resection of 3.5 or 4 parathyroid glands and transcervical thymectomy (TCT). We reviewed our experience with initial operation for primary HPT to determine the outcome and utility of routine TCT. Methods: All patients with MEN1 who underwent initial neck exploration from 1993 to 2007 under an institutional review board-approved protocol were reviewed. Results: We identified 66 patients with initial operation for HPT in MEN1. In 34 patients, 4 glands were found; in 32 patients, <4 glands were found. In 2 of the 34 (6%) and 17 of the 32 (53%), intrathymic parathyroid tissue was found on permanent pathology. No thymic carcinoid tissue was found in any specimen. Conclusion: These data highlight the importance of performing TCT when <4 entopic parathyroid glands are found at first operation.

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The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism

Abstract

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