The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism

Anathea C. Powell, H. Richard Alexander, James F. Pingpank, Seth M. Steinberg, Monica Skarulis, David L. Bartlett, Sunita Agarwal, Craig Cochran, Geoffrey Seidel, Douglas Fraker, Marybeth S. Hughes, Robert T. Jensen, Stephen J. Marx, Steven K. Libutti

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: Operation for multiple endocrine neoplasia (MEN)1-related hyperparathyroidism (HPT) includes a neck exploration with resection of 3.5 or 4 parathyroid glands and transcervical thymectomy (TCT). We reviewed our experience with initial operation for primary HPT to determine the outcome and utility of routine TCT. Methods: All patients with MEN1 who underwent initial neck exploration from 1993 to 2007 under an institutional review board-approved protocol were reviewed. Results: We identified 66 patients with initial operation for HPT in MEN1. In 34 patients, 4 glands were found; in 32 patients, <4 glands were found. In 2 of the 34 (6%) and 17 of the 32 (53%), intrathymic parathyroid tissue was found on permanent pathology. No thymic carcinoid tissue was found in any specimen. Conclusion: These data highlight the importance of performing TCT when <4 entopic parathyroid glands are found at first operation.

Original languageEnglish (US)
Pages (from-to)878-884
Number of pages7
JournalSurgery
Volume144
Issue number6
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Surgery

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    Powell, A. C., Alexander, H. R., Pingpank, J. F., Steinberg, S. M., Skarulis, M., Bartlett, D. L., Agarwal, S., Cochran, C., Seidel, G., Fraker, D., Hughes, M. S., Jensen, R. T., Marx, S. J., & Libutti, S. K. (2008). The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism. Surgery, 144(6), 878-884. https://doi.org/10.1016/j.surg.2008.08.031