The use of microsatellite variation to infer population structure and demographic history in a natural model system

David B. Goldstein, Gary W. Roemer, Deborah A. Smith, David E. Reich, Aviv Bergman, Robert K. Wayne

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

To assess the reliability of genetic markers it is important to compare inferences that are based on them to a priori expectations. In this article we present an analysis of microsatellite variation within and among populations of island foxes (Urocyon littoralis) on California's Channel Islands. We first show that microsatellite variation at a moderate number of loci (19) can provide an essentially perfect description of the boundaries between populations and an accurate representation of their historical relationships. We also show that the pattern of variation across unlinked microsatellite loci can be used to test whether population size has been constant or increasing. Application of these approaches to the island fox system indicates that microsatellite variation may carry considerably more information about population history than in currently being used.

Original languageEnglish (US)
Pages (from-to)797-801
Number of pages5
JournalGenetics
Volume151
Issue number2
StatePublished - Feb 1999
Externally publishedYes

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Microsatellite Repeats
Demography
Islands
Population
Channel Islands
Population Density
Genetic Markers

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Goldstein, D. B., Roemer, G. W., Smith, D. A., Reich, D. E., Bergman, A., & Wayne, R. K. (1999). The use of microsatellite variation to infer population structure and demographic history in a natural model system. Genetics, 151(2), 797-801.

The use of microsatellite variation to infer population structure and demographic history in a natural model system. / Goldstein, David B.; Roemer, Gary W.; Smith, Deborah A.; Reich, David E.; Bergman, Aviv; Wayne, Robert K.

In: Genetics, Vol. 151, No. 2, 02.1999, p. 797-801.

Research output: Contribution to journalArticle

Goldstein, DB, Roemer, GW, Smith, DA, Reich, DE, Bergman, A & Wayne, RK 1999, 'The use of microsatellite variation to infer population structure and demographic history in a natural model system', Genetics, vol. 151, no. 2, pp. 797-801.
Goldstein, David B. ; Roemer, Gary W. ; Smith, Deborah A. ; Reich, David E. ; Bergman, Aviv ; Wayne, Robert K. / The use of microsatellite variation to infer population structure and demographic history in a natural model system. In: Genetics. 1999 ; Vol. 151, No. 2. pp. 797-801.
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