The use of magnetic resonance imaging (MRI) in the study of manganese neurotoxicity

Vanessa A. Fitsanakis, Na Zhang, Malcolm J. Avison, John C. Gore, Judy L. Aschner, Michael Aschner

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Manganese (Mn), an element found in many foods, is an important and essential nutrient for proper health and maintenance. It is toxic in high doses, however, and exposure to excessive levels can result in the onset of a neurological disorder similar to, but distinct from, Parkinson's disease. Historically, Mn neurotoxicity was most commonly associated with various occupations, such as Mn mining, welding and steel production. More recently, increases in both blood and brain Mn levels have been observed in persons with liver disease or those receiving prolonged parenteral nutrition. Additionally, rodent data suggest that iron deficiency and anemia may be risk factors for Mn neurotoxicity. Clinically, brain Mn accumulation can be monitored in vivo using non-invasive magnetic resonance imaging (MRI) due to the paramagnetic nature of this element. Indeed, MRI has been used in a variety of settings to evaluate the brain Mn deposition in various populations. This review focuses on the use of MRI technology in studies related specifically to Mn neurotoxicity. Thus, we will examine reports using MRI to confirm brain Mn accumulation in human populations, and conclude with data from non-human primate and rodent models of Mn neurotoxicity.

Original languageEnglish (US)
Pages (from-to)798-806
Number of pages9
JournalNeuroToxicology
Volume27
Issue number5
DOIs
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Magnetic resonance
Manganese
Magnetic Resonance Imaging
Imaging techniques
Brain
Manganese mines
Rodentia
Welding
Food
Poisons
Steel
Iron-Deficiency Anemias
Nutrition
Parenteral Nutrition
Liver
Nutrients
Nervous System Diseases
Occupations
Primates
Population

Keywords

  • Human studies
  • Magnetic resonance imaging (MRI)
  • Manganese
  • Review
  • Rodent studies

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

The use of magnetic resonance imaging (MRI) in the study of manganese neurotoxicity. / Fitsanakis, Vanessa A.; Zhang, Na; Avison, Malcolm J.; Gore, John C.; Aschner, Judy L.; Aschner, Michael.

In: NeuroToxicology, Vol. 27, No. 5, 09.2006, p. 798-806.

Research output: Contribution to journalArticle

Fitsanakis, Vanessa A. ; Zhang, Na ; Avison, Malcolm J. ; Gore, John C. ; Aschner, Judy L. ; Aschner, Michael. / The use of magnetic resonance imaging (MRI) in the study of manganese neurotoxicity. In: NeuroToxicology. 2006 ; Vol. 27, No. 5. pp. 798-806.
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