The use of DREADDs (designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

Daniela Cassataro, Lucas L. Sjulson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.

Original languageEnglish (US)
Title of host publicationDesigner Receptors Exclusively Activated by Designer Drugs
PublisherSpringer New York
Pages95-108
Number of pages14
ISBN (Electronic)9781493929443
ISBN (Print)9781493929436
DOIs
StatePublished - Sep 4 2015
Externally publishedYes

Keywords

  • Addiction
  • CNO
  • DREADDs
  • Mouse behavior
  • Reverse pharmacogenetics
  • Transgenic mice

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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