The use of DREADDs (designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

Daniela Cassataro; Lucas Sjulson

doi:10.1007/978-1-4939-2944-3_6

The use of DREADDs (designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.

Original language	English (US)
Title of host publication	Designer Receptors Exclusively Activated by Designer Drugs
Publisher	Springer New York
Pages	95-108
Number of pages	14
ISBN (Electronic)	9781493929443
ISBN (Print)	9781493929436
DOIs	https://doi.org/10.1007/978-1-4939-2944-3_6
State	Published - Sep 4 2015
Externally published	Yes

Keywords

Addiction
CNO
DREADDs
Mouse behavior
Reverse pharmacogenetics
Transgenic mice

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1007/978-1-4939-2944-3_6

Cite this

@inbook{155eeb6865bb49d4b21ee6a4371f2aef,

title = "The use of DREADDs (designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models",

abstract = "Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.",

keywords = "Addiction, CNO, DREADDs, Mouse behavior, Reverse pharmacogenetics, Transgenic mice",

author = "Daniela Cassataro and Lucas Sjulson",

year = "2015",

month = sep,

day = "4",

doi = "10.1007/978-1-4939-2944-3_6",

language = "English (US)",

isbn = "9781493929436",

pages = "95--108",

booktitle = "Designer Receptors Exclusively Activated by Designer Drugs",

publisher = "Springer New York",

}

TY - CHAP

T1 - The use of DREADDs (designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

AU - Cassataro, Daniela

AU - Sjulson, Lucas

PY - 2015/9/4

Y1 - 2015/9/4

N2 - Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.

AB - Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.

KW - Addiction

KW - CNO

KW - DREADDs

KW - Mouse behavior

KW - Reverse pharmacogenetics

KW - Transgenic mice

UR - http://www.scopus.com/inward/record.url?scp=84955129503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955129503&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-2944-3_6

DO - 10.1007/978-1-4939-2944-3_6

M3 - Chapter

AN - SCOPUS:84955129503

SN - 9781493929436

SP - 95

EP - 108

BT - Designer Receptors Exclusively Activated by Designer Drugs

PB - Springer New York

ER -

The use of DREADDs (designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this