The use of DREADDs (Designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

Daniela Cassataro, Lucas Sjulson

Research output: Contribution to journalArticle

Abstract

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.

Original languageEnglish (US)
Pages (from-to)95-108
Number of pages14
JournalNeuromethods
Volume108
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

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Keywords

  • Addiction
  • CNO
  • DREADDs
  • Mouse behavior
  • Reverse pharmacogenetics
  • Transgenic mice

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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