The ultrastructure of the peritoneal membrane in chronically dialysed rats

K. Wieczorowska-Tobis, A. Polubińska, R. Brelińska, A. Breborowicz

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The model to estimate peritoneal function in chronically dialysed rats was previously presented by us. The aim of the paper is to report the findings obtained in electron microscopy of peritoneal biopsies from Wistar rats dialysed for 1 month with high glucose dialysis solution. In control animals, thin mesothelial cells were covered with microvilli. The submesothelial tissue was composed of sparse bundles of parallelly oriented collagen fibers with a few resting cells. In chronically dialysed rats, mesothelial cell layer was thicker and cells were fully packed with intracellular structures, mainly secretory granules with a homogeneous content. The submesothelial tissue was expanded due to the increased amount of collagen fibers, oedema and increased amount of submesothelial cells which were activated. The use of electron microscopy to study the peritoneum in dialysed rats is an excellent supplement to the chronic functional model of peritoneal dialysis in rats.

Original languageEnglish (US)
Pages (from-to)209-210
Number of pages2
JournalFolia Histochemica et Cytobiologica
Volume39
Issue number2
StatePublished - Jan 1 2001

Keywords

  • Dialysis
  • Peritoneum
  • Rat
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Wieczorowska-Tobis, K., Polubińska, A., Brelińska, R., & Breborowicz, A. (2001). The ultrastructure of the peritoneal membrane in chronically dialysed rats. Folia Histochemica et Cytobiologica, 39(2), 209-210.