The ultrastructure of circulating immunocytes in guillain-barré syndrome

John N. Whitaker, Asao Hirano, Stuart D. Cook, Peter C. Dowling

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A large population of primitive basophilic mononuclear cells (immunocytes), capable of synthesizing DNA, occurs in the peripheral blood of patients with GBS. In this study, the electron-microscopic features of these circulating atypical mononuclear cells were correlated with their autoradiographic and light-microscopic characteristics. Circulating immunocytes in GBS have ultrastructural features which are consistent with their high metabolic activity and are indistinguishable from some of the cells infiltrating the nerve roots in GBS. This provides further evidence that these cells may play an important role in GBS pathogenesis.

Original languageEnglish (US)
Pages (from-to)765-770
Number of pages6
JournalNeurology
Volume20
Issue number8
StatePublished - 1970

Fingerprint

Electrons
Neurons
Light
DNA
Population
Cells
Syndrome
Nerve
Blood

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Whitaker, J. N., Hirano, A., Cook, S. D., & Dowling, P. C. (1970). The ultrastructure of circulating immunocytes in guillain-barré syndrome. Neurology, 20(8), 765-770.

The ultrastructure of circulating immunocytes in guillain-barré syndrome. / Whitaker, John N.; Hirano, Asao; Cook, Stuart D.; Dowling, Peter C.

In: Neurology, Vol. 20, No. 8, 1970, p. 765-770.

Research output: Contribution to journalArticle

Whitaker, JN, Hirano, A, Cook, SD & Dowling, PC 1970, 'The ultrastructure of circulating immunocytes in guillain-barré syndrome', Neurology, vol. 20, no. 8, pp. 765-770.
Whitaker JN, Hirano A, Cook SD, Dowling PC. The ultrastructure of circulating immunocytes in guillain-barré syndrome. Neurology. 1970;20(8):765-770.
Whitaker, John N. ; Hirano, Asao ; Cook, Stuart D. ; Dowling, Peter C. / The ultrastructure of circulating immunocytes in guillain-barré syndrome. In: Neurology. 1970 ; Vol. 20, No. 8. pp. 765-770.
@article{351b419433fe42cabfc8d04ecffe99b4,
title = "The ultrastructure of circulating immunocytes in guillain-barr{\'e} syndrome",
abstract = "A large population of primitive basophilic mononuclear cells (immunocytes), capable of synthesizing DNA, occurs in the peripheral blood of patients with GBS. In this study, the electron-microscopic features of these circulating atypical mononuclear cells were correlated with their autoradiographic and light-microscopic characteristics. Circulating immunocytes in GBS have ultrastructural features which are consistent with their high metabolic activity and are indistinguishable from some of the cells infiltrating the nerve roots in GBS. This provides further evidence that these cells may play an important role in GBS pathogenesis.",
author = "Whitaker, {John N.} and Asao Hirano and Cook, {Stuart D.} and Dowling, {Peter C.}",
year = "1970",
language = "English (US)",
volume = "20",
pages = "765--770",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - The ultrastructure of circulating immunocytes in guillain-barré syndrome

AU - Whitaker, John N.

AU - Hirano, Asao

AU - Cook, Stuart D.

AU - Dowling, Peter C.

PY - 1970

Y1 - 1970

N2 - A large population of primitive basophilic mononuclear cells (immunocytes), capable of synthesizing DNA, occurs in the peripheral blood of patients with GBS. In this study, the electron-microscopic features of these circulating atypical mononuclear cells were correlated with their autoradiographic and light-microscopic characteristics. Circulating immunocytes in GBS have ultrastructural features which are consistent with their high metabolic activity and are indistinguishable from some of the cells infiltrating the nerve roots in GBS. This provides further evidence that these cells may play an important role in GBS pathogenesis.

AB - A large population of primitive basophilic mononuclear cells (immunocytes), capable of synthesizing DNA, occurs in the peripheral blood of patients with GBS. In this study, the electron-microscopic features of these circulating atypical mononuclear cells were correlated with their autoradiographic and light-microscopic characteristics. Circulating immunocytes in GBS have ultrastructural features which are consistent with their high metabolic activity and are indistinguishable from some of the cells infiltrating the nerve roots in GBS. This provides further evidence that these cells may play an important role in GBS pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0014834072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014834072&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 765

EP - 770

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 8

ER -