@article{c8f0169645f745bcb37be5e188b77aca,
title = "The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens",
abstract = "CD1b is an antigen-presenting molecule that mediates recognition of bacterial lipid and glycolipid antigens by specific T cells. We demonstrate that the nine-amino acid cytoplasmic tail of CD1b contains all of the signals required for its normal endosomal targeting, and that the single cytoplasmic tyrosine is a critical component of the targeting motif. Mutant forms of CD1b lacking the endosomal targeting motif are expressed at high levels on the cell surface but are unable to efficiently present lipid antigens acquired either exogenously or from live intracellular organisms. These results define the functional role of the CD1b targeting motif in a physiologic setting and demonstrate its importance in delivery of this antigen-presenting molecule to appropriate intracellular compartments.",
author = "Jackman, {Robin M.} and Steffen Stenger and Agnes Lee and Moody, {D. Branch} and Rogers, {Rick A.} and Niazi, {Kayvan R.} and Masahiko Sugita and Modlin, {Robert L.} and Peters, {Peter J.} and Porcelli, {Steven A.}",
note = "Funding Information: We thank Jean Lai and Juliete Mervis for expert help with confocal microscopy. We also gratefully acknowledge the following colleagues for providing antisera: Minoru Fukuda (Lamp-1), Peter Cresswell (HLA-DMβ), and Hidde Ploegh (class II α chain). R. M. J. was supported by a National Science Foundation predoctoral fellowship, D. B. M. by National Institute of Arthritis and Musculoskeletal Disease-National Institutes of Health grant AR01988, and R. A. R. by National Heart, Lung, and Blood Institute–National Institutes of Health grants HL33009 and HL43510. This research was supported by the Arthritis Foundation (S. A. P, Investigator Award), a grant from the American Cancer Society, and National Institutes of Health grant AI40135 to S. A. P.",
year = "1998",
month = mar,
doi = "10.1016/S1074-7613(00)80539-7",
language = "English (US)",
volume = "8",
pages = "341--351",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "3",
}