Abstract
The mammalian central nervous system (CNS) possesses a unique and specialized capillary adaptation, referred to as the blood-brain barrier (BBB). The BBB maintains an optimal neuronal microenvironment, regulating blood-tissue exchange of macromolecules and nutrients. The BBB is characterized by individual endothelial cells that are continuously linked by tight junctions, inhibiting the diffusion of macromolecules and solutes between adjacent endothelial cells. This review will focus on pertinent issues to BBB maintenance, and survey recent dogmas on the transport mechanisms for the essential metal, manganese, across this barrier. Specifically, putative carriers for manganese into and out of the brain will be discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 311-314 |
| Number of pages | 4 |
| Journal | NeuroToxicology |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2006 |
| Externally published | Yes |
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Keywords
- Blood-brain barrier
- Divalent metal transporter-1 (DMT-1)
- Manganese
- Neurotoxicity
- Transferrin
- Transport
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Neuroscience(all)
- Toxicology
Cite this
The transport of manganese across the blood-brain barrier. / Aschner, Michael.
In: NeuroToxicology, Vol. 27, No. 3, 05.2006, p. 311-314.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The transport of manganese across the blood-brain barrier
AU - Aschner, Michael
PY - 2006/5
Y1 - 2006/5
N2 - The mammalian central nervous system (CNS) possesses a unique and specialized capillary adaptation, referred to as the blood-brain barrier (BBB). The BBB maintains an optimal neuronal microenvironment, regulating blood-tissue exchange of macromolecules and nutrients. The BBB is characterized by individual endothelial cells that are continuously linked by tight junctions, inhibiting the diffusion of macromolecules and solutes between adjacent endothelial cells. This review will focus on pertinent issues to BBB maintenance, and survey recent dogmas on the transport mechanisms for the essential metal, manganese, across this barrier. Specifically, putative carriers for manganese into and out of the brain will be discussed.
AB - The mammalian central nervous system (CNS) possesses a unique and specialized capillary adaptation, referred to as the blood-brain barrier (BBB). The BBB maintains an optimal neuronal microenvironment, regulating blood-tissue exchange of macromolecules and nutrients. The BBB is characterized by individual endothelial cells that are continuously linked by tight junctions, inhibiting the diffusion of macromolecules and solutes between adjacent endothelial cells. This review will focus on pertinent issues to BBB maintenance, and survey recent dogmas on the transport mechanisms for the essential metal, manganese, across this barrier. Specifically, putative carriers for manganese into and out of the brain will be discussed.
KW - Blood-brain barrier
KW - Divalent metal transporter-1 (DMT-1)
KW - Manganese
KW - Neurotoxicity
KW - Transferrin
KW - Transport
UR - http://www.scopus.com/inward/record.url?scp=33646171934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646171934&partnerID=8YFLogxK
U2 - 10.1016/j.neuro.2005.09.002
DO - 10.1016/j.neuro.2005.09.002
M3 - Article
C2 - 16460806
AN - SCOPUS:33646171934
VL - 27
SP - 311
EP - 314
JO - NeuroToxicology
JF - NeuroToxicology
SN - 0161-813X
IS - 3
ER -