The transport of manganese across the blood-brain barrier

Michael Aschner

doi:10.1016/j.neuro.2005.09.002

The transport of manganese across the blood-brain barrier

Michael Aschner

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The mammalian central nervous system (CNS) possesses a unique and specialized capillary adaptation, referred to as the blood-brain barrier (BBB). The BBB maintains an optimal neuronal microenvironment, regulating blood-tissue exchange of macromolecules and nutrients. The BBB is characterized by individual endothelial cells that are continuously linked by tight junctions, inhibiting the diffusion of macromolecules and solutes between adjacent endothelial cells. This review will focus on pertinent issues to BBB maintenance, and survey recent dogmas on the transport mechanisms for the essential metal, manganese, across this barrier. Specifically, putative carriers for manganese into and out of the brain will be discussed.

Original language	English (US)
Pages (from-to)	311-314
Number of pages	4
Journal	Neurotoxicology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.neuro.2005.09.002
State	Published - May 2006
Externally published	Yes

Keywords

Blood-brain barrier
Divalent metal transporter-1 (DMT-1)
Manganese
Neurotoxicity
Transferrin
Transport

ASJC Scopus subject areas

General Neuroscience
Toxicology

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10.1016/j.neuro.2005.09.002

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abstract = "The mammalian central nervous system (CNS) possesses a unique and specialized capillary adaptation, referred to as the blood-brain barrier (BBB). The BBB maintains an optimal neuronal microenvironment, regulating blood-tissue exchange of macromolecules and nutrients. The BBB is characterized by individual endothelial cells that are continuously linked by tight junctions, inhibiting the diffusion of macromolecules and solutes between adjacent endothelial cells. This review will focus on pertinent issues to BBB maintenance, and survey recent dogmas on the transport mechanisms for the essential metal, manganese, across this barrier. Specifically, putative carriers for manganese into and out of the brain will be discussed.",

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AB - The mammalian central nervous system (CNS) possesses a unique and specialized capillary adaptation, referred to as the blood-brain barrier (BBB). The BBB maintains an optimal neuronal microenvironment, regulating blood-tissue exchange of macromolecules and nutrients. The BBB is characterized by individual endothelial cells that are continuously linked by tight junctions, inhibiting the diffusion of macromolecules and solutes between adjacent endothelial cells. This review will focus on pertinent issues to BBB maintenance, and survey recent dogmas on the transport mechanisms for the essential metal, manganese, across this barrier. Specifically, putative carriers for manganese into and out of the brain will be discussed.

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KW - Manganese

KW - Neurotoxicity

KW - Transferrin

KW - Transport

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The transport of manganese across the blood-brain barrier

Abstract

Keywords

ASJC Scopus subject areas

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