The transcription factor ETS1 in lymphomas: Friend or foe?

Monica Testoni, Elaine Yee Lin Chung, Valdemar Priebe, Francesco Bertoni

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

ETS1 is a member of the ETS family of transcription factors, which contains many cancer genes. ETS1 gene is mapped at 11q24.3, a chromosomal region that is often the site of genomic rearrangements in hematological cancers. ETS1 is expressed in a variety of cells, including B and T lymphocytes. ETS1 is important in various biological processes such as development, differentiation, proliferation, apoptosis, migration and tissue remodeling. It acts as an oncogene controlling invasive and angiogenic behavior of malignant cells in multiple human cancers. In particular, ETS1 deregulation has been reported in diffuse large B-cell lymphoma, in Burkitt lymphoma and in Hodgkin lymphoma. Here, we summarize the function of ETS1 in normal cells, with a particular emphasis on lymphocytes, and its possible role as an oncogene or tumor suppressor gene in the different mature B cell lymphomas.

Original languageEnglish (US)
Pages (from-to)1975-1980
Number of pages6
JournalLeukemia and Lymphoma
Volume56
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • BLIMP1
  • Diffuse large B-cell lymphoma
  • ETS1
  • Lymphoma and Hodgkin disease
  • Transcription factor

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Testoni, M., Chung, E. Y. L., Priebe, V., & Bertoni, F. (2015). The transcription factor ETS1 in lymphomas: Friend or foe? Leukemia and Lymphoma, 56(7), 1975-1980. https://doi.org/10.3109/10428194.2014.981670