TY - JOUR
T1 - The transcription factor ETS1 in lymphomas
T2 - Friend or foe?
AU - Testoni, Monica
AU - Chung, Elaine Yee Lin
AU - Priebe, Valdemar
AU - Bertoni, Francesco
N1 - Publisher Copyright:
© 2015 Informa UK, Ltd.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - ETS1 is a member of the ETS family of transcription factors, which contains many cancer genes. ETS1 gene is mapped at 11q24.3, a chromosomal region that is often the site of genomic rearrangements in hematological cancers. ETS1 is expressed in a variety of cells, including B and T lymphocytes. ETS1 is important in various biological processes such as development, differentiation, proliferation, apoptosis, migration and tissue remodeling. It acts as an oncogene controlling invasive and angiogenic behavior of malignant cells in multiple human cancers. In particular, ETS1 deregulation has been reported in diffuse large B-cell lymphoma, in Burkitt lymphoma and in Hodgkin lymphoma. Here, we summarize the function of ETS1 in normal cells, with a particular emphasis on lymphocytes, and its possible role as an oncogene or tumor suppressor gene in the different mature B cell lymphomas.
AB - ETS1 is a member of the ETS family of transcription factors, which contains many cancer genes. ETS1 gene is mapped at 11q24.3, a chromosomal region that is often the site of genomic rearrangements in hematological cancers. ETS1 is expressed in a variety of cells, including B and T lymphocytes. ETS1 is important in various biological processes such as development, differentiation, proliferation, apoptosis, migration and tissue remodeling. It acts as an oncogene controlling invasive and angiogenic behavior of malignant cells in multiple human cancers. In particular, ETS1 deregulation has been reported in diffuse large B-cell lymphoma, in Burkitt lymphoma and in Hodgkin lymphoma. Here, we summarize the function of ETS1 in normal cells, with a particular emphasis on lymphocytes, and its possible role as an oncogene or tumor suppressor gene in the different mature B cell lymphomas.
KW - BLIMP1
KW - Diffuse large B-cell lymphoma
KW - ETS1
KW - Lymphoma and Hodgkin disease
KW - Transcription factor
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U2 - 10.3109/10428194.2014.981670
DO - 10.3109/10428194.2014.981670
M3 - Review article
C2 - 25363344
AN - SCOPUS:84938153308
SN - 1042-8194
VL - 56
SP - 1975
EP - 1980
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 7
ER -
