The time is right to focus on model organism metabolomes

Arthur S. Edison, Robert D. Hall, Christophe Junot, Peter D. Karp, Irwin J. Kurland, Robert Mistrik, Laura K. Reed, Kazuki Saito, Reza M. Salek, Christoph Steinbeck, Lloyd W. Sumner, Mark R. Viant

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Model organisms are an essential component of biological and biomedical research that can be used to study specific biological processes. These organisms are in part selected for facile experimental study. However, just as importantly, intensive study of a small number of model organisms yields important synergies as discoveries in one area of science for a given organism shed light on biological processes in other areas, even for other organisms. Furthermore, the extensive knowledge bases compiled for each model organism enable systems-level understandings of these species, which enhance the overall biological and biomedical knowledge for all organisms, including humans. Building upon extensive genomics research, we argue that the time is now right to focus intensively on model organism metabolomes. We propose a grand challenge for metabolomics studies of model organisms: to identify and map all metabolites onto metabolic pathways, to develop quantitative metabolic models for model organisms, and to relate organism metabolic pathways within the context of evolutionary metabolomics, i.e., phylometabolomics. These efforts should focus on a series of established model organisms in microbial, animal and plant research.

Original languageEnglish (US)
Article number8
JournalMetabolites
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Biological Phenomena
Metabolomics
Metabolome
Metabolic Networks and Pathways
Knowledge Bases
Genomics
Biomedical Research
Metabolites
Animals
Research

Keywords

  • Arabidopsis thaliana
  • Caenorhabditis elegans
  • Danio rerio
  • Daphnia magna
  • Drosophila melanogaster
  • Escherichia coli
  • Mus musculus
  • Oryza sativa
  • Saccharomyces cerevisiae
  • Solanum lycopersicum

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism

Cite this

Edison, A. S., Hall, R. D., Junot, C., Karp, P. D., Kurland, I. J., Mistrik, R., ... Viant, M. R. (2016). The time is right to focus on model organism metabolomes. Metabolites, 6(1), [8]. https://doi.org/10.3390/metabo6010008

The time is right to focus on model organism metabolomes. / Edison, Arthur S.; Hall, Robert D.; Junot, Christophe; Karp, Peter D.; Kurland, Irwin J.; Mistrik, Robert; Reed, Laura K.; Saito, Kazuki; Salek, Reza M.; Steinbeck, Christoph; Sumner, Lloyd W.; Viant, Mark R.

In: Metabolites, Vol. 6, No. 1, 8, 01.01.2016.

Research output: Contribution to journalArticle

Edison, AS, Hall, RD, Junot, C, Karp, PD, Kurland, IJ, Mistrik, R, Reed, LK, Saito, K, Salek, RM, Steinbeck, C, Sumner, LW & Viant, MR 2016, 'The time is right to focus on model organism metabolomes', Metabolites, vol. 6, no. 1, 8. https://doi.org/10.3390/metabo6010008
Edison AS, Hall RD, Junot C, Karp PD, Kurland IJ, Mistrik R et al. The time is right to focus on model organism metabolomes. Metabolites. 2016 Jan 1;6(1). 8. https://doi.org/10.3390/metabo6010008
Edison, Arthur S. ; Hall, Robert D. ; Junot, Christophe ; Karp, Peter D. ; Kurland, Irwin J. ; Mistrik, Robert ; Reed, Laura K. ; Saito, Kazuki ; Salek, Reza M. ; Steinbeck, Christoph ; Sumner, Lloyd W. ; Viant, Mark R. / The time is right to focus on model organism metabolomes. In: Metabolites. 2016 ; Vol. 6, No. 1.
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