TY - JOUR
T1 - The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease
AU - Tomer, Yaron
AU - Greenberg, David
PY - 2004/7/1
Y1 - 2004/7/1
N2 - Recent linkage and association studies provide evidence for thyroglobulin (Tg) being an autoimmune thyroid disease (AITD) susceptibility gene. The Tg locus has been reported to be linked with AITD in two independent studies, and further analysis demonstrated that markers within the Tg gene were associated with AITD. Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene were shown to be associated with autoimmune thyroiditis in both mice and humans. If Tg is confirmed as a susceptibility gene for AITD, it could provide a novel therapeutic target.
AB - Recent linkage and association studies provide evidence for thyroglobulin (Tg) being an autoimmune thyroid disease (AITD) susceptibility gene. The Tg locus has been reported to be linked with AITD in two independent studies, and further analysis demonstrated that markers within the Tg gene were associated with AITD. Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene were shown to be associated with autoimmune thyroiditis in both mice and humans. If Tg is confirmed as a susceptibility gene for AITD, it could provide a novel therapeutic target.
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U2 - 10.1016/j.molmed.2004.05.002
DO - 10.1016/j.molmed.2004.05.002
M3 - Short survey
C2 - 15242677
AN - SCOPUS:3042787719
SN - 1471-4914
VL - 10
SP - 306
EP - 308
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 7
ER -