The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease

Yaron Tomer, David Greenberg

Research output: Contribution to journalShort survey

16 Scopus citations

Abstract

Recent linkage and association studies provide evidence for thyroglobulin (Tg) being an autoimmune thyroid disease (AITD) susceptibility gene. The Tg locus has been reported to be linked with AITD in two independent studies, and further analysis demonstrated that markers within the Tg gene were associated with AITD. Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene were shown to be associated with autoimmune thyroiditis in both mice and humans. If Tg is confirmed as a susceptibility gene for AITD, it could provide a novel therapeutic target.

Original languageEnglish (US)
Pages (from-to)306-308
Number of pages3
JournalTrends in Molecular Medicine
Volume10
Issue number7
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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