The Temporal Relationship between Pain Intensity and Pain Interference and Incident Dementia

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3 Citations (Scopus)

Abstract

BACKGROUND: Chronic pain is common among older adults and is associated with cognitive dysfunction based on cross-sectional studies. However, the longitudinal association between chronic pain and incident dementia in community-based samples is unknown. OBJECTIVE: We aimed to evaluate the association of pain intensity and pain interference with incident dementia in a community-based sample of older adults. METHODS: Participants were 1,114 individuals 70 years of age or older from Einstein Aging Study (EAS), a longitudinal cohort study of community-dwelling older adults in the Bronx County, NY. The primary outcome measure was incident dementia, diagnosed using DSM-IV criteria. Pain intensity and interference in the month prior to first annual visit were measured using items from the SF-36 questionnaire. Pain intensity and pain interference were assessed as predictors of time to incident dementia using Cox proportionate hazards models while controlling for potential confounders. RESULTS: Among participants, 114 individuals developed dementia over an average 4.4 years (SD=3.1) of follow-up. Models showed that pain intensity had no significant effect on time to developing dementia, whereas higher levels of pain interference were associated with a higher risk of dementia. In the model that included both pain intensity and interference as predictors of incident dementia, pain interference had a significant effect on incident dementia, and pain intensity remained non-significant. CONCLUSION: As a potential remediable risk factor, the mechanisms linking pain interference to cognitive decline merit further exploration.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalCurrent Alzheimer research
Volume16
Issue number2
DOIs
StatePublished - Jan 1 2019

Fingerprint

Dementia
Pain
Chronic Pain
Independent Living
Proportional Hazards Models
Diagnostic and Statistical Manual of Mental Disorders
Longitudinal Studies
Cohort Studies
Cross-Sectional Studies
Outcome Assessment (Health Care)

Keywords

  • Alzheimer's disease
  • dementia
  • Pain intensity
  • pain interference
  • remediable risk factor.

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

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title = "The Temporal Relationship between Pain Intensity and Pain Interference and Incident Dementia",
abstract = "BACKGROUND: Chronic pain is common among older adults and is associated with cognitive dysfunction based on cross-sectional studies. However, the longitudinal association between chronic pain and incident dementia in community-based samples is unknown. OBJECTIVE: We aimed to evaluate the association of pain intensity and pain interference with incident dementia in a community-based sample of older adults. METHODS: Participants were 1,114 individuals 70 years of age or older from Einstein Aging Study (EAS), a longitudinal cohort study of community-dwelling older adults in the Bronx County, NY. The primary outcome measure was incident dementia, diagnosed using DSM-IV criteria. Pain intensity and interference in the month prior to first annual visit were measured using items from the SF-36 questionnaire. Pain intensity and pain interference were assessed as predictors of time to incident dementia using Cox proportionate hazards models while controlling for potential confounders. RESULTS: Among participants, 114 individuals developed dementia over an average 4.4 years (SD=3.1) of follow-up. Models showed that pain intensity had no significant effect on time to developing dementia, whereas higher levels of pain interference were associated with a higher risk of dementia. In the model that included both pain intensity and interference as predictors of incident dementia, pain interference had a significant effect on incident dementia, and pain intensity remained non-significant. CONCLUSION: As a potential remediable risk factor, the mechanisms linking pain interference to cognitive decline merit further exploration.",
keywords = "Alzheimer's disease, dementia, Pain intensity, pain interference, remediable risk factor.",
author = "Ali Ezzati and Cuiling Wang and Katz, {Mindy Joy} and Derby, {Carol A.} and Zammit, {Andrea R.} and Zimmerman, {Molly E.} and Pavlovic, {Jelena M.} and Sliwinski, {Martin J.} and Lipton, {Richard B.}",
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T1 - The Temporal Relationship between Pain Intensity and Pain Interference and Incident Dementia

AU - Ezzati, Ali

AU - Wang, Cuiling

AU - Katz, Mindy Joy

AU - Derby, Carol A.

AU - Zammit, Andrea R.

AU - Zimmerman, Molly E.

AU - Pavlovic, Jelena M.

AU - Sliwinski, Martin J.

AU - Lipton, Richard B.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUND: Chronic pain is common among older adults and is associated with cognitive dysfunction based on cross-sectional studies. However, the longitudinal association between chronic pain and incident dementia in community-based samples is unknown. OBJECTIVE: We aimed to evaluate the association of pain intensity and pain interference with incident dementia in a community-based sample of older adults. METHODS: Participants were 1,114 individuals 70 years of age or older from Einstein Aging Study (EAS), a longitudinal cohort study of community-dwelling older adults in the Bronx County, NY. The primary outcome measure was incident dementia, diagnosed using DSM-IV criteria. Pain intensity and interference in the month prior to first annual visit were measured using items from the SF-36 questionnaire. Pain intensity and pain interference were assessed as predictors of time to incident dementia using Cox proportionate hazards models while controlling for potential confounders. RESULTS: Among participants, 114 individuals developed dementia over an average 4.4 years (SD=3.1) of follow-up. Models showed that pain intensity had no significant effect on time to developing dementia, whereas higher levels of pain interference were associated with a higher risk of dementia. In the model that included both pain intensity and interference as predictors of incident dementia, pain interference had a significant effect on incident dementia, and pain intensity remained non-significant. CONCLUSION: As a potential remediable risk factor, the mechanisms linking pain interference to cognitive decline merit further exploration.

AB - BACKGROUND: Chronic pain is common among older adults and is associated with cognitive dysfunction based on cross-sectional studies. However, the longitudinal association between chronic pain and incident dementia in community-based samples is unknown. OBJECTIVE: We aimed to evaluate the association of pain intensity and pain interference with incident dementia in a community-based sample of older adults. METHODS: Participants were 1,114 individuals 70 years of age or older from Einstein Aging Study (EAS), a longitudinal cohort study of community-dwelling older adults in the Bronx County, NY. The primary outcome measure was incident dementia, diagnosed using DSM-IV criteria. Pain intensity and interference in the month prior to first annual visit were measured using items from the SF-36 questionnaire. Pain intensity and pain interference were assessed as predictors of time to incident dementia using Cox proportionate hazards models while controlling for potential confounders. RESULTS: Among participants, 114 individuals developed dementia over an average 4.4 years (SD=3.1) of follow-up. Models showed that pain intensity had no significant effect on time to developing dementia, whereas higher levels of pain interference were associated with a higher risk of dementia. In the model that included both pain intensity and interference as predictors of incident dementia, pain interference had a significant effect on incident dementia, and pain intensity remained non-significant. CONCLUSION: As a potential remediable risk factor, the mechanisms linking pain interference to cognitive decline merit further exploration.

KW - Alzheimer's disease

KW - dementia

KW - Pain intensity

KW - pain interference

KW - remediable risk factor.

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