The TB structural genomics consortium: Providing a structural foundation for drug discovery

Celia W. Goulding, Marcin Apostol, Daniel H. Anderson, Harindarpal S. Gill, Clare V. Smith, Mack R. Kuo, Jin KukYang, Geoffrey S. Waldo, Se Won Suh, Radha Chauhan, Avinash Kale, Nandita Bachhawat, Shekhar C. Mande, Jodie M. Johnston, J. Shaun Lott, Edward N. Baker, Vickery L. Arcus, David Leys, Kirsty J. McLean, Andrew W. MunroJoel Berendzen, Vivek Sharma, Min S. Park, David Eisenberg, James Sacchettini, Tom Alber, Bernhard Rupp, William Jacobs, Thomas C. Terwilliger

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

Original languageEnglish (US)
Pages (from-to)121-141
Number of pages21
JournalCurrent Drug Targets - Infectious Disorders
Volume2
Issue number2
DOIs
StatePublished - Jun 27 2002
Externally publishedYes

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Drug Discovery
Genomics
Tuberculosis
Proteins
Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Microbiology (medical)

Cite this

Goulding, C. W., Apostol, M., Anderson, D. H., Gill, H. S., Smith, C. V., Kuo, M. R., ... Terwilliger, T. C. (2002). The TB structural genomics consortium: Providing a structural foundation for drug discovery. Current Drug Targets - Infectious Disorders, 2(2), 121-141. https://doi.org/10.2174/1568005023342551

The TB structural genomics consortium : Providing a structural foundation for drug discovery. / Goulding, Celia W.; Apostol, Marcin; Anderson, Daniel H.; Gill, Harindarpal S.; Smith, Clare V.; Kuo, Mack R.; KukYang, Jin; Waldo, Geoffrey S.; Won Suh, Se; Chauhan, Radha; Kale, Avinash; Bachhawat, Nandita; Mande, Shekhar C.; Johnston, Jodie M.; Lott, J. Shaun; Baker, Edward N.; Arcus, Vickery L.; Leys, David; McLean, Kirsty J.; Munro, Andrew W.; Berendzen, Joel; Sharma, Vivek; Park, Min S.; Eisenberg, David; Sacchettini, James; Alber, Tom; Rupp, Bernhard; Jacobs, William; Terwilliger, Thomas C.

In: Current Drug Targets - Infectious Disorders, Vol. 2, No. 2, 27.06.2002, p. 121-141.

Research output: Contribution to journalReview article

Goulding, CW, Apostol, M, Anderson, DH, Gill, HS, Smith, CV, Kuo, MR, KukYang, J, Waldo, GS, Won Suh, S, Chauhan, R, Kale, A, Bachhawat, N, Mande, SC, Johnston, JM, Lott, JS, Baker, EN, Arcus, VL, Leys, D, McLean, KJ, Munro, AW, Berendzen, J, Sharma, V, Park, MS, Eisenberg, D, Sacchettini, J, Alber, T, Rupp, B, Jacobs, W & Terwilliger, TC 2002, 'The TB structural genomics consortium: Providing a structural foundation for drug discovery', Current Drug Targets - Infectious Disorders, vol. 2, no. 2, pp. 121-141. https://doi.org/10.2174/1568005023342551
Goulding, Celia W. ; Apostol, Marcin ; Anderson, Daniel H. ; Gill, Harindarpal S. ; Smith, Clare V. ; Kuo, Mack R. ; KukYang, Jin ; Waldo, Geoffrey S. ; Won Suh, Se ; Chauhan, Radha ; Kale, Avinash ; Bachhawat, Nandita ; Mande, Shekhar C. ; Johnston, Jodie M. ; Lott, J. Shaun ; Baker, Edward N. ; Arcus, Vickery L. ; Leys, David ; McLean, Kirsty J. ; Munro, Andrew W. ; Berendzen, Joel ; Sharma, Vivek ; Park, Min S. ; Eisenberg, David ; Sacchettini, James ; Alber, Tom ; Rupp, Bernhard ; Jacobs, William ; Terwilliger, Thomas C. / The TB structural genomics consortium : Providing a structural foundation for drug discovery. In: Current Drug Targets - Infectious Disorders. 2002 ; Vol. 2, No. 2. pp. 121-141.
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