The TB structural genomics consortium: Providing a structural foundation for drug discovery

Celia W. Goulding; Marcin Apostol; Daniel H. Anderson; Harindarpal S. Gill; Clare V. Smith; Mack R. Kuo; Jin KukYang; Geoffrey S. Waldo; Se Won Suh; Radha Chauhan; Avinash Kale; Nandita Bachhawat; Shekhar C. Mande; Jodie M. Johnston; J. Shaun Lott; Edward N. Baker; Vickery L. Arcus; David Leys; Kirsty J. McLean; Andrew W. Munro; Joel Berendzen; Vivek Sharma; Min S. Park; David Eisenberg; James Sacchettini; Tom Alber; Bernhard Rupp; William Jacobs; Thomas C. Terwilliger

doi:10.2174/1568005023342551

The TB structural genomics consortium: Providing a structural foundation for drug discovery

Celia W. Goulding, Marcin Apostol, Daniel H. Anderson, Harindarpal S. Gill, Clare V. Smith, Mack R. Kuo, Jin KukYang, Geoffrey S. Waldo, Se Won Suh, Radha Chauhan, Avinash Kale, Nandita Bachhawat, Shekhar C. Mande, Jodie M. Johnston, J. Shaun Lott, Edward N. Baker, Vickery L. Arcus, David Leys, Kirsty J. McLean, Andrew W. MunroJoel Berendzen, Vivek Sharma, Min S. Park, David Eisenberg, James Sacchettini, Tom Alber, Bernhard Rupp, William Jacobs, Thomas C. Terwilliger

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

Original language	English (US)
Pages (from-to)	121-141
Number of pages	21
Journal	Current Drug Targets - Infectious Disorders
Volume	2
Issue number	2
DOIs	https://doi.org/10.2174/1568005023342551
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1568005023342551

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Goulding, C. W., Apostol, M., Anderson, D. H., Gill, H. S., Smith, C. V., Kuo, M. R., KukYang, J., Waldo, G. S., Won Suh, S., Chauhan, R., Kale, A., Bachhawat, N., Mande, S. C., Johnston, J. M., Lott, J. S., Baker, E. N., Arcus, V. L., Leys, D., McLean, K. J., ... Terwilliger, T. C. (2002). The TB structural genomics consortium: Providing a structural foundation for drug discovery. Current Drug Targets - Infectious Disorders, 2(2), 121-141. https://doi.org/10.2174/1568005023342551

Goulding, CW, Apostol, M, Anderson, DH, Gill, HS, Smith, CV, Kuo, MR, KukYang, J, Waldo, GS, Won Suh, S, Chauhan, R, Kale, A, Bachhawat, N, Mande, SC, Johnston, JM, Lott, JS, Baker, EN, Arcus, VL, Leys, D, McLean, KJ, Munro, AW, Berendzen, J, Sharma, V, Park, MS, Eisenberg, D, Sacchettini, J, Alber, T, Rupp, B, Jacobs, W & Terwilliger, TC 2002, 'The TB structural genomics consortium: Providing a structural foundation for drug discovery', Current Drug Targets - Infectious Disorders, vol. 2, no. 2, pp. 121-141. https://doi.org/10.2174/1568005023342551

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title = "The TB structural genomics consortium: Providing a structural foundation for drug discovery",

abstract = "Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.",

author = "Goulding, {Celia W.} and Marcin Apostol and Anderson, {Daniel H.} and Gill, {Harindarpal S.} and Smith, {Clare V.} and Kuo, {Mack R.} and Jin KukYang and Waldo, {Geoffrey S.} and {Won Suh}, Se and Radha Chauhan and Avinash Kale and Nandita Bachhawat and Mande, {Shekhar C.} and Johnston, {Jodie M.} and Lott, {J. Shaun} and Baker, {Edward N.} and Arcus, {Vickery L.} and David Leys and McLean, {Kirsty J.} and Munro, {Andrew W.} and Joel Berendzen and Vivek Sharma and Park, {Min S.} and David Eisenberg and James Sacchettini and Tom Alber and Bernhard Rupp and William Jacobs and Terwilliger, {Thomas C.}",

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doi = "10.2174/1568005023342551",

language = "English (US)",

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T1 - The TB structural genomics consortium

T2 - Providing a structural foundation for drug discovery

AU - Goulding, Celia W.

AU - Apostol, Marcin

AU - Anderson, Daniel H.

AU - Gill, Harindarpal S.

AU - Smith, Clare V.

AU - Kuo, Mack R.

AU - KukYang, Jin

AU - Waldo, Geoffrey S.

AU - Won Suh, Se

AU - Chauhan, Radha

AU - Kale, Avinash

AU - Bachhawat, Nandita

AU - Mande, Shekhar C.

AU - Johnston, Jodie M.

AU - Lott, J. Shaun

AU - Baker, Edward N.

AU - Arcus, Vickery L.

AU - Leys, David

AU - McLean, Kirsty J.

AU - Munro, Andrew W.

AU - Berendzen, Joel

AU - Sharma, Vivek

AU - Park, Min S.

AU - Eisenberg, David

AU - Sacchettini, James

AU - Alber, Tom

AU - Rupp, Bernhard

AU - Jacobs, William

AU - Terwilliger, Thomas C.

PY - 2002

Y1 - 2002

N2 - Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

AB - Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.

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The TB structural genomics consortium: Providing a structural foundation for drug discovery

Abstract

ASJC Scopus subject areas

UN SDGs

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