The TB structural genomics consortium: A resource for Mycobacterium tuberculosis biology

T. C. Terwilliger, M. S. Park, G. S. Waldo, J. Berendzen, L. W. Hung, C. Y. Kim, C. V. Smith, J. C. Sacchettini, M. Bellinzoni, R. Bossi, E. De Rossi, A. Mattevi, A. Milano, G. Riccardi, M. Rizzi, M. M. Roberts, A. R. Coker, G. Fossati, P. Mascagni, A. R.M. CoatesS. P. Wood, C. W. Goulding, M. I. Apostol, D. H. Anderson, H. S. Gill, D. S. Eisenberg, B. Taneja, S. Mande, E. Pohl, V. Lamzin, P. Tucker, M. Wilmanns, C. Colovos, W. Meyer-Klaucke, A. W. Munro, K. J. McLean, K. R. Marshall, D. Leys, J. K. Yang, H. J. Yoon, B. I. Lee, M. G. Lee, J. E. Kwak, B. W. Han, J. Y. Lee, S. H. Baek, S. W. Suh, M. M. Komen, V. L. Arcus, E. N. Baker, J. S. Lott, W. Jacobs, T. Alber, B. Rupp

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

The TB Structural Genomics Consortium is an organization devoted to encouraging, coordinating, and facilitating the determination and analysis of structures of proteins from Mycobacterium tuberculosis. The Consortium members hope to work together with other M. tuberculosis researchers to identify M. tuberculosis proteins for which structural information could provide important biological information, to analyze and interpret structures of M. tuberculosis proteins, and to work collaboratively to test ideas about M. tuberculosis protein function that are suggested by structure or related to structural information. This review describes the TB Structural Genomics Consortium and some of the proteins for which the Consortium is in the progress of determining three-dimensional structures.

Original languageEnglish (US)
Pages (from-to)223-249
Number of pages27
JournalTuberculosis
Volume83
Issue number4
DOIs
StatePublished - Jan 1 2003

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Keywords

  • Drug discovery
  • Mycobacterium tuberculosis
  • Protein structure
  • Structural genomics
  • X-ray crystallography

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Terwilliger, T. C., Park, M. S., Waldo, G. S., Berendzen, J., Hung, L. W., Kim, C. Y., Smith, C. V., Sacchettini, J. C., Bellinzoni, M., Bossi, R., De Rossi, E., Mattevi, A., Milano, A., Riccardi, G., Rizzi, M., Roberts, M. M., Coker, A. R., Fossati, G., Mascagni, P., ... Rupp, B. (2003). The TB structural genomics consortium: A resource for Mycobacterium tuberculosis biology. Tuberculosis, 83(4), 223-249. https://doi.org/10.1016/S1472-9792(03)00051-9