The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

Gary B. Evans; Graeme J. Gainsford; Vern L. Schramm; Peter C. Tyler

doi:10.1016/j.tetlet.2014.11.113

The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

Gary B. Evans, Graeme J. Gainsford, Vern L. Schramm, Peter C. Tyler

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The synthetically challenging S_N2 transition state mimic for thymidine phosphorylase, along with its phosphonate analogue, were synthesised via a modified Corey-Link reaction in good overall yields and ensuring the correct stereochemical outcome.

Original language	English (US)
Pages (from-to)	406-409
Number of pages	4
Journal	Tetrahedron Letters
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.tetlet.2014.11.113
State	Published - Jan 8 2015
Externally published	Yes

Keywords

Cancer
Corey-Link
Enzyme
Thymidine phosphorylase
Transition state analogue

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2014.11.113

Cite this

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title = "The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase",

abstract = "The synthetically challenging SN2 transition state mimic for thymidine phosphorylase, along with its phosphonate analogue, were synthesised via a modified Corey-Link reaction in good overall yields and ensuring the correct stereochemical outcome.",

keywords = "Cancer, Corey-Link, Enzyme, Thymidine phosphorylase, Transition state analogue",

author = "Evans, {Gary B.} and Gainsford, {Graeme J.} and Schramm, {Vern L.} and Tyler, {Peter C.}",

year = "2015",

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T1 - The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

AU - Evans, Gary B.

AU - Gainsford, Graeme J.

AU - Schramm, Vern L.

AU - Tyler, Peter C.

PY - 2015/1/8

Y1 - 2015/1/8

N2 - The synthetically challenging SN2 transition state mimic for thymidine phosphorylase, along with its phosphonate analogue, were synthesised via a modified Corey-Link reaction in good overall yields and ensuring the correct stereochemical outcome.

AB - The synthetically challenging SN2 transition state mimic for thymidine phosphorylase, along with its phosphonate analogue, were synthesised via a modified Corey-Link reaction in good overall yields and ensuring the correct stereochemical outcome.

KW - Cancer

KW - Corey-Link

KW - Enzyme

KW - Thymidine phosphorylase

KW - Transition state analogue

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VL - 56

SP - 406

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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