The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

Gary B. Evans, Graeme J. Gainsford, Vern L. Schramm, Peter C. Tyler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The synthetically challenging SN2 transition state mimic for thymidine phosphorylase, along with its phosphonate analogue, were synthesised via a modified Corey-Link reaction in good overall yields and ensuring the correct stereochemical outcome.

Original languageEnglish (US)
Pages (from-to)406-409
Number of pages4
JournalTetrahedron Letters
Volume56
Issue number2
DOIs
StatePublished - Jan 8 2015
Externally publishedYes

Fingerprint

Thymidine Phosphorylase
Organophosphonates

Keywords

  • Cancer
  • Corey-Link
  • Enzyme
  • Thymidine phosphorylase
  • Transition state analogue

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase. / Evans, Gary B.; Gainsford, Graeme J.; Schramm, Vern L.; Tyler, Peter C.

In: Tetrahedron Letters, Vol. 56, No. 2, 08.01.2015, p. 406-409.

Research output: Contribution to journalArticle

Evans, Gary B. ; Gainsford, Graeme J. ; Schramm, Vern L. ; Tyler, Peter C. / The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase. In: Tetrahedron Letters. 2015 ; Vol. 56, No. 2. pp. 406-409.
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