The synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. VI. Assembly of IgM proteins

J. Buxbaum, Matthew D. Scharff

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The study of the synthesis, assembly, and secretion of IgM by seven murine myeloma tumors has revealed that free mu chain can be detected intracellularly after release from the ribosome. It combines with light chains to form μL. The major intracellular protein in six of the seven tumors was the 8S subunit. One tumor contained considerable amounts of 19S material intracellularly. Those tumors that did not contain 19S IgM intracellularly appeared to assemble the subunits outside the cell.

Original languageEnglish (US)
Pages (from-to)278-288
Number of pages11
JournalJournal of Experimental Medicine
Volume138
Issue number1
StatePublished - 1973

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gamma-Globulins
Immunoglobulin M
Neoplasms
Proteins
L Forms
Ribosomes
Light

ASJC Scopus subject areas

  • Immunology

Cite this

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