The pathways of immunoglobulin synthesis and assembly have been studied in bone marrow cells obtained from 9 patients whose serum contained substantial amounts of homogeneous IgA1 myeloma proteins. Eight of the 9 cell samples synthesized light chains in excess of heavy chains. A variety of assembly intermediates, including αL, α2 and α2L, were also noted. The major intracellular molecule in most cases was α2L2 although larger polymers were noted in the secretions and serum of most of the patients. In only one instance was a large amount of polymer larger than α2L2 found inside the cell. As is the case for the assembly for IgM, the sites of IgA polymer assembly and factors responsible for the observed heterogeneity have not yet been established.
ASJC Scopus subject areas
- Immunology and Allergy