The synthesis and assembly of immunoglobulins by malignant human plasmacytes. III. Heterogeneity in IgA polymer assembly

J. N. Buxbaum, S. Zolla, Matthew D. Scharff, E. C. Franklin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The pathways of immunoglobulin synthesis and assembly have been studied in bone marrow cells obtained from 9 patients whose serum contained substantial amounts of homogeneous IgA1 myeloma proteins. Eight of the 9 cell samples synthesized light chains in excess of heavy chains. A variety of assembly intermediates, including αL, α2 and α2L, were also noted. The major intracellular molecule in most cases was α2L2 although larger polymers were noted in the secretions and serum of most of the patients. In only one instance was a large amount of polymer larger than α2L2 found inside the cell. As is the case for the assembly for IgM, the sites of IgA polymer assembly and factors responsible for the observed heterogeneity have not yet been established.

Original languageEnglish (US)
Pages (from-to)367-369
Number of pages3
JournalEuropean Journal of Immunology
Volume4
Issue number5
StatePublished - 1974

Fingerprint

Plasma Cells
Immunoglobulin A
Immunoglobulins
Polymers
Myeloma Proteins
Serum
Bone Marrow Cells
Immunoglobulin M
Light

ASJC Scopus subject areas

  • Immunology

Cite this

The synthesis and assembly of immunoglobulins by malignant human plasmacytes. III. Heterogeneity in IgA polymer assembly. / Buxbaum, J. N.; Zolla, S.; Scharff, Matthew D.; Franklin, E. C.

In: European Journal of Immunology, Vol. 4, No. 5, 1974, p. 367-369.

Research output: Contribution to journalArticle

@article{ee1840ace3404d09bd7d2622ccdb9d31,
title = "The synthesis and assembly of immunoglobulins by malignant human plasmacytes. III. Heterogeneity in IgA polymer assembly",
abstract = "The pathways of immunoglobulin synthesis and assembly have been studied in bone marrow cells obtained from 9 patients whose serum contained substantial amounts of homogeneous IgA1 myeloma proteins. Eight of the 9 cell samples synthesized light chains in excess of heavy chains. A variety of assembly intermediates, including αL, α2 and α2L, were also noted. The major intracellular molecule in most cases was α2L2 although larger polymers were noted in the secretions and serum of most of the patients. In only one instance was a large amount of polymer larger than α2L2 found inside the cell. As is the case for the assembly for IgM, the sites of IgA polymer assembly and factors responsible for the observed heterogeneity have not yet been established.",
author = "Buxbaum, {J. N.} and S. Zolla and Scharff, {Matthew D.} and Franklin, {E. C.}",
year = "1974",
language = "English (US)",
volume = "4",
pages = "367--369",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "5",

}

TY - JOUR

T1 - The synthesis and assembly of immunoglobulins by malignant human plasmacytes. III. Heterogeneity in IgA polymer assembly

AU - Buxbaum, J. N.

AU - Zolla, S.

AU - Scharff, Matthew D.

AU - Franklin, E. C.

PY - 1974

Y1 - 1974

N2 - The pathways of immunoglobulin synthesis and assembly have been studied in bone marrow cells obtained from 9 patients whose serum contained substantial amounts of homogeneous IgA1 myeloma proteins. Eight of the 9 cell samples synthesized light chains in excess of heavy chains. A variety of assembly intermediates, including αL, α2 and α2L, were also noted. The major intracellular molecule in most cases was α2L2 although larger polymers were noted in the secretions and serum of most of the patients. In only one instance was a large amount of polymer larger than α2L2 found inside the cell. As is the case for the assembly for IgM, the sites of IgA polymer assembly and factors responsible for the observed heterogeneity have not yet been established.

AB - The pathways of immunoglobulin synthesis and assembly have been studied in bone marrow cells obtained from 9 patients whose serum contained substantial amounts of homogeneous IgA1 myeloma proteins. Eight of the 9 cell samples synthesized light chains in excess of heavy chains. A variety of assembly intermediates, including αL, α2 and α2L, were also noted. The major intracellular molecule in most cases was α2L2 although larger polymers were noted in the secretions and serum of most of the patients. In only one instance was a large amount of polymer larger than α2L2 found inside the cell. As is the case for the assembly for IgM, the sites of IgA polymer assembly and factors responsible for the observed heterogeneity have not yet been established.

UR - http://www.scopus.com/inward/record.url?scp=0016146957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016146957&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 367

EP - 369

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 5

ER -