The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache

Matthew S. Robbins; Carrie E. Robertson; Eugene Kaplan; Jessica Ailani; Larry Charleston; Deena Kuruvilla; Andrew Blumenfeld; Randall Berliner; Noah L. Rosen; Robert Duarte; Jaskiran Vidwan; Rashmi B. Halker; Nicole Gill; Avi Ashkenazi

doi:10.1111/head.12729

The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache

Matthew S. Robbins, Carrie E. Robertson, Eugene Kaplan, Jessica Ailani, Larry Charleston, Deena Kuruvilla, Andrew Blumenfeld, Randall Berliner, Noah L. Rosen, Robert Duarte, Jaskiran Vidwan, Rashmi B. Halker, Nicole Gill, Avi Ashkenazi

Neurology

Research output: Contribution to journal › Review article › peer-review

114 Scopus citations

Abstract

The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.

Original language	English (US)
Pages (from-to)	240-258
Number of pages	19
Journal	Headache
Volume	56
Issue number	2
DOIs	https://doi.org/10.1111/head.12729
State	Published - Feb 1 2016

Keywords

ablation
cluster
ganglion
headache
migraine
neuralgia
neurostimulation
pterygopalatine
sphenopalatine

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1111/head.12729

Cite this

@article{7abdd16a570741958412533432d3abd6,

title = "The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache",

abstract = "The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.",

keywords = "ablation, cluster, ganglion, headache, migraine, neuralgia, neurostimulation, pterygopalatine, sphenopalatine",

author = "Robbins, {Matthew S.} and Robertson, {Carrie E.} and Eugene Kaplan and Jessica Ailani and Larry Charleston and Deena Kuruvilla and Andrew Blumenfeld and Randall Berliner and Rosen, {Noah L.} and Robert Duarte and Jaskiran Vidwan and Halker, {Rashmi B.} and Nicole Gill and Avi Ashkenazi",

note = "Publisher Copyright: {\textcopyright} 2015 American Headache Society.",

year = "2016",

month = feb,

day = "1",

doi = "10.1111/head.12729",

language = "English (US)",

volume = "56",

pages = "240--258",

journal = "Headache",

issn = "0017-8748",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - The Sphenopalatine Ganglion

T2 - Anatomy, Pathophysiology, and Therapeutic Targeting in Headache

AU - Robbins, Matthew S.

AU - Robertson, Carrie E.

AU - Kaplan, Eugene

AU - Ailani, Jessica

AU - Charleston, Larry

AU - Kuruvilla, Deena

AU - Blumenfeld, Andrew

AU - Berliner, Randall

AU - Rosen, Noah L.

AU - Duarte, Robert

AU - Vidwan, Jaskiran

AU - Halker, Rashmi B.

AU - Gill, Nicole

AU - Ashkenazi, Avi

PY - 2016/2/1

Y1 - 2016/2/1

N2 - The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.

AB - The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.

KW - ablation

KW - cluster

KW - ganglion

KW - headache

KW - migraine

KW - neuralgia

KW - neurostimulation

KW - pterygopalatine

KW - sphenopalatine

UR - http://www.scopus.com/inward/record.url?scp=84958952122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958952122&partnerID=8YFLogxK

U2 - 10.1111/head.12729

DO - 10.1111/head.12729

M3 - Review article

C2 - 26615983

AN - SCOPUS:84958952122

SN - 0017-8748

VL - 56

SP - 240

EP - 258

JO - Headache

JF - Headache

IS - 2

ER -

The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this