The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache

Matthew S. Robbins, Carrie E. Robertson, Eugene Kaplan, Jessica Ailani, Larry Charleston, Deena Kuruvilla, Andrew Blumenfeld, Randall Berliner, Noah L. Rosen, Robert Duarte, Jaskiran Vidwan, Rashmi B. Halker, Nicole Gill, Avi Ashkenazi

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.

Original languageEnglish (US)
Pages (from-to)240-258
Number of pages19
JournalHeadache
Volume56
Issue number2
DOIs
StatePublished - Feb 1 2016

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Keywords

  • ablation
  • cluster
  • ganglion
  • headache
  • migraine
  • neuralgia
  • neurostimulation
  • pterygopalatine
  • sphenopalatine

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Robbins, M. S., Robertson, C. E., Kaplan, E., Ailani, J., Charleston, L., Kuruvilla, D., Blumenfeld, A., Berliner, R., Rosen, N. L., Duarte, R., Vidwan, J., Halker, R. B., Gill, N., & Ashkenazi, A. (2016). The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache. Headache, 56(2), 240-258. https://doi.org/10.1111/head.12729