The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation

A. S. Weintraub, J. Connors, A. Carey, V. Blanco, R. S. Green

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective : To determine risk factors for acute kidney injury (AKI) in preterm infants as a function of time of onset. Study Design : In this 5 1/2-year, single-center, retrospective study, incidence and timing of AKI was determined using modified Acute Kidney Injury Network criteria. Characteristics of newborns with and without AKI were compared by chi square and t-tests. Logistic regression was used to examine risk factors for AKI as a function of time of onset and potential confounders.Result:AKI occurred in 30.3% of 357 neonates; 72.2% was stage 1. Gestational ages (GA), initial Cr, maternal magnesium and volume resuscitation were associated with early AKI (days 0 to 1). Volume resuscitation, umbilical arterial line and receipt of non-steroidal anti-inflammatory drug (NSAID) for patent ductus arteriosus were associated with intermediate AKI (days 2 to 5). GA, steroids for early hypotension, necrotizing enterocolitis and sepsis were associated with late AKI (≥day 6). Conclusion : Stage 1 AKI is a common morbidity in our population. Risk factors for AKI in our population differed with time of onset.

Original languageEnglish (US)
Pages (from-to)474-480
Number of pages7
JournalJournal of Perinatology
Volume36
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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Acute Kidney Injury
Premature Infants
Pregnancy
Resuscitation
Gestational Age
Newborn Infant
Umbilicus
Vascular Access Devices
Necrotizing Enterocolitis
Patent Ductus Arteriosus
Chi-Square Distribution
Hypotension
Magnesium
Population
Sepsis
Anti-Inflammatory Agents
Retrospective Studies
Logistic Models
Steroids
Mothers

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation. / Weintraub, A. S.; Connors, J.; Carey, A.; Blanco, V.; Green, R. S.

In: Journal of Perinatology, Vol. 36, No. 6, 01.06.2016, p. 474-480.

Research output: Contribution to journalArticle

Weintraub, A. S. ; Connors, J. ; Carey, A. ; Blanco, V. ; Green, R. S. / The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation. In: Journal of Perinatology. 2016 ; Vol. 36, No. 6. pp. 474-480.
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