The spectrum of brain MR abnormalities in sickle-cell disease

A report from the cooperative study of sickle cell disease

Franklin G. Moser, Scott T. Miller, Jacqueline A. Bello, Charles H. Pegelow, Robert A. Zimmerman, Winfred C. Wang, Kwaku Ohene-Frempong, Alan Schwartz, Elliott P. Vichinsky, Dianne Gallagher, Thomas R. Kinney

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

PURPOSE: To define the spectrum of abnormalities in sickle-cell disease, including infarction, atrophy, and hemorrhage, that are identified by brain MR imaging. METHODS: All MR studies included T1, T2, and intermediate pulse sequences. Images were interpreted without knowledge of the clinical history or neurologic examination findings. Brain MR imaging was performed in 312 children with sickle-cell disease. RESULTS: Seventy patients (22%) had infarction/ischemia and/or atrophy. Infarction/ischemia was noted in 39 children (13%) who had no history of a stroke (the 'silent' group). The prevalence rates for silent lesions were 17% for sickle-cell anemia and 3% for hemoglobin sickle-cell disease. For patients with sickle-cell anemia and a history of cerebrovascular accident, infarction/ischemia lesions typically involved both cortex and deep white matter, while silent lesions usually were confined to deep white matter. Within the age range studied, the prevalence of infarction/ischemia did not increase significantly with age, although older patients with lesions had more lesions than did younger patients with lesions. CONCLUSIONS: Brain MR imaging showed infarction/ischemia in the absence of a recognized cerebrovascular accident in 13% of patients. The prevalence of these lesions did not increase significantly between the ages of 6 and 14 years, suggesting that lesions are present by age 6. However, the increase in the average number of lesions per patient with age may indicate progressive brain injury.

Original languageEnglish (US)
Pages (from-to)965-972
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume17
Issue number5
StatePublished - 1996

Fingerprint

Sickle Cell Anemia
Infarction
Ischemia
Brain
Neuroimaging
Stroke
Atrophy
Neurologic Examination
Neurologic Manifestations
Brain Injuries
Hemoglobins
Hemorrhage

Keywords

  • Brain, magnetic resonance
  • Children, diseases
  • Sickle-cell disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Moser, F. G., Miller, S. T., Bello, J. A., Pegelow, C. H., Zimmerman, R. A., Wang, W. C., ... Kinney, T. R. (1996). The spectrum of brain MR abnormalities in sickle-cell disease: A report from the cooperative study of sickle cell disease. American Journal of Neuroradiology, 17(5), 965-972.

The spectrum of brain MR abnormalities in sickle-cell disease : A report from the cooperative study of sickle cell disease. / Moser, Franklin G.; Miller, Scott T.; Bello, Jacqueline A.; Pegelow, Charles H.; Zimmerman, Robert A.; Wang, Winfred C.; Ohene-Frempong, Kwaku; Schwartz, Alan; Vichinsky, Elliott P.; Gallagher, Dianne; Kinney, Thomas R.

In: American Journal of Neuroradiology, Vol. 17, No. 5, 1996, p. 965-972.

Research output: Contribution to journalArticle

Moser, FG, Miller, ST, Bello, JA, Pegelow, CH, Zimmerman, RA, Wang, WC, Ohene-Frempong, K, Schwartz, A, Vichinsky, EP, Gallagher, D & Kinney, TR 1996, 'The spectrum of brain MR abnormalities in sickle-cell disease: A report from the cooperative study of sickle cell disease', American Journal of Neuroradiology, vol. 17, no. 5, pp. 965-972.
Moser, Franklin G. ; Miller, Scott T. ; Bello, Jacqueline A. ; Pegelow, Charles H. ; Zimmerman, Robert A. ; Wang, Winfred C. ; Ohene-Frempong, Kwaku ; Schwartz, Alan ; Vichinsky, Elliott P. ; Gallagher, Dianne ; Kinney, Thomas R. / The spectrum of brain MR abnormalities in sickle-cell disease : A report from the cooperative study of sickle cell disease. In: American Journal of Neuroradiology. 1996 ; Vol. 17, No. 5. pp. 965-972.
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