The sodium/iodide symporter (NIS)

Characterization, regulation, and medical significance

Orsolya Dohán, Antonio De La Vieja, Viktoriya Paroder, Claudia Riedel, Mona Artani, Mia Reed, Christopher S. Ginter, Nancy Carrasco

Research output: Contribution to journalArticle

556 Citations (Scopus)

Abstract

The Na+/I- symporter (NIS) is an integral plasma membrane glycoprotein that mediates active I- transport into the thyroid follicular cells, the first step in thyroid hormone biosynthesis. NIS-mediated thyroidal I- transport from the bloodstream to the colloid is a vectorial process made possible by the selective targeting of NIS to the basolateral membrane. NIS also mediates active I- transport in other tissues, including salivary glands, gastric mucosa, and lactating mammary gland, in which it translocates I- into the milk for thyroid hormone biosynthesis by the nursing newborn. NIS provides the basis for the effective diagnostic and therapeutic management of thyroid cancer and its metastases with radioiodide. NIS research has proceeded at an astounding pace after the 1996 isolation of the rat NIS cDNA, comprising the elucidation of NIS secondary structure and topology, biogenesis and posttranslational modifications, transcriptional and posttranscriptional regulation, electrophysiological analysis, isolation of the human NIS cDNA, and determination of the human NIS genomic organization. Clinically related topics include the analysis of congenital I- transport defect-causing NIS mutations and the role of NIS in thyroid cancer. NIS has been transduced into various kinds of cancer cells to render them susceptible to destruction with radioiodide. Most dramatically, the discovery of endogenous NIS expression in more than 80% of human breast cancer samples has raised the possibility that radioiodide may be a valuable novel tool in breast cancer diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)48-77
Number of pages30
JournalEndocrine Reviews
Volume24
Issue number1
DOIs
StatePublished - Feb 2003

Fingerprint

Symporters
Active Biological Transport
sodium-iodide symporter
Thyroid Hormones
Thyroid Neoplasms
Complementary DNA
Breast Neoplasms
Membrane Glycoproteins
Colloids
Human Mammary Glands
Post Translational Protein Processing
Gastric Mucosa
Salivary Glands

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Dohán, O., De La Vieja, A., Paroder, V., Riedel, C., Artani, M., Reed, M., ... Carrasco, N. (2003). The sodium/iodide symporter (NIS): Characterization, regulation, and medical significance. Endocrine Reviews, 24(1), 48-77. https://doi.org/10.1210/er.2001-0029

The sodium/iodide symporter (NIS) : Characterization, regulation, and medical significance. / Dohán, Orsolya; De La Vieja, Antonio; Paroder, Viktoriya; Riedel, Claudia; Artani, Mona; Reed, Mia; Ginter, Christopher S.; Carrasco, Nancy.

In: Endocrine Reviews, Vol. 24, No. 1, 02.2003, p. 48-77.

Research output: Contribution to journalArticle

Dohán, O, De La Vieja, A, Paroder, V, Riedel, C, Artani, M, Reed, M, Ginter, CS & Carrasco, N 2003, 'The sodium/iodide symporter (NIS): Characterization, regulation, and medical significance', Endocrine Reviews, vol. 24, no. 1, pp. 48-77. https://doi.org/10.1210/er.2001-0029
Dohán O, De La Vieja A, Paroder V, Riedel C, Artani M, Reed M et al. The sodium/iodide symporter (NIS): Characterization, regulation, and medical significance. Endocrine Reviews. 2003 Feb;24(1):48-77. https://doi.org/10.1210/er.2001-0029
Dohán, Orsolya ; De La Vieja, Antonio ; Paroder, Viktoriya ; Riedel, Claudia ; Artani, Mona ; Reed, Mia ; Ginter, Christopher S. ; Carrasco, Nancy. / The sodium/iodide symporter (NIS) : Characterization, regulation, and medical significance. In: Endocrine Reviews. 2003 ; Vol. 24, No. 1. pp. 48-77.
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