TY - JOUR
T1 - The significance of T suppressor cells in the development of autoimmunity
AU - Tomer, Yaron
AU - Shoenfeld, Yehuda
N1 - Funding Information:
Correspondence to: Prof. Y. Shoenfeld, MD, Head of Department Medicine ‘B’, Sheba Medical Center, Tel-Hashomer, 52621, Israel. This work was supported by a grant given on behalf of Mr Sal Domb.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/12
Y1 - 1989/12
N2 - Despite intensive research, autoimmune-disease pathogenesis is still an enigma, but in the past decade Ts-cell defects have assumed a central role in this pathogenesis. Ts-cell dysfunctions have been reported in numerous autoimmune diseases (e.g. SLE, autoimmune thyroid disease, myasthenia gravis) and in animal models of autoimmune diseases. Therefore, it is currently believed that Ts cells are responsible for maintaining self-tolerance and that perturbations in suppressor functions may initiate development of autoimmune diseases. Ts-cell abnormalities can result from LCTA production, intrinsic biochemical alterations, genetic susceptibility, or environmental factors. Since Ts-cells dysfunctions are believed to initiate autoimmunity, it may be possible to treat autoimmune diseases by correcting the suppressor defects, and indeed, preliminary trials in this direction are promising.
AB - Despite intensive research, autoimmune-disease pathogenesis is still an enigma, but in the past decade Ts-cell defects have assumed a central role in this pathogenesis. Ts-cell dysfunctions have been reported in numerous autoimmune diseases (e.g. SLE, autoimmune thyroid disease, myasthenia gravis) and in animal models of autoimmune diseases. Therefore, it is currently believed that Ts cells are responsible for maintaining self-tolerance and that perturbations in suppressor functions may initiate development of autoimmune diseases. Ts-cell abnormalities can result from LCTA production, intrinsic biochemical alterations, genetic susceptibility, or environmental factors. Since Ts-cells dysfunctions are believed to initiate autoimmunity, it may be possible to treat autoimmune diseases by correcting the suppressor defects, and indeed, preliminary trials in this direction are promising.
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U2 - 10.1016/0896-8411(89)90002-4
DO - 10.1016/0896-8411(89)90002-4
M3 - Article
C2 - 2575908
AN - SCOPUS:0024839206
SN - 0896-8411
VL - 2
SP - 739
EP - 758
JO - Journal of Autoimmunity
JF - Journal of Autoimmunity
IS - 6
ER -