The significance of T suppressor cells in the development of autoimmunity

Yaron Tomer, Yehuda Shoenfeld

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Despite intensive research, autoimmune-disease pathogenesis is still an enigma, but in the past decade Ts-cell defects have assumed a central role in this pathogenesis. Ts-cell dysfunctions have been reported in numerous autoimmune diseases (e.g. SLE, autoimmune thyroid disease, myasthenia gravis) and in animal models of autoimmune diseases. Therefore, it is currently believed that Ts cells are responsible for maintaining self-tolerance and that perturbations in suppressor functions may initiate development of autoimmune diseases. Ts-cell abnormalities can result from LCTA production, intrinsic biochemical alterations, genetic susceptibility, or environmental factors. Since Ts-cells dysfunctions are believed to initiate autoimmunity, it may be possible to treat autoimmune diseases by correcting the suppressor defects, and indeed, preliminary trials in this direction are promising.

Original languageEnglish (US)
Pages (from-to)739-758
Number of pages20
JournalJournal of Autoimmunity
Volume2
Issue number6
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Autoimmunity
Autoimmune Diseases
Self Tolerance
Myasthenia Gravis
Thyroid Diseases
Genetic Predisposition to Disease
Molecular Biology
Animal Models
Research

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The significance of T suppressor cells in the development of autoimmunity. / Tomer, Yaron; Shoenfeld, Yehuda.

In: Journal of Autoimmunity, Vol. 2, No. 6, 1989, p. 739-758.

Research output: Contribution to journalArticle

@article{88b107c9ce554b62ad4048aa6d613b5d,
title = "The significance of T suppressor cells in the development of autoimmunity",
abstract = "Despite intensive research, autoimmune-disease pathogenesis is still an enigma, but in the past decade Ts-cell defects have assumed a central role in this pathogenesis. Ts-cell dysfunctions have been reported in numerous autoimmune diseases (e.g. SLE, autoimmune thyroid disease, myasthenia gravis) and in animal models of autoimmune diseases. Therefore, it is currently believed that Ts cells are responsible for maintaining self-tolerance and that perturbations in suppressor functions may initiate development of autoimmune diseases. Ts-cell abnormalities can result from LCTA production, intrinsic biochemical alterations, genetic susceptibility, or environmental factors. Since Ts-cells dysfunctions are believed to initiate autoimmunity, it may be possible to treat autoimmune diseases by correcting the suppressor defects, and indeed, preliminary trials in this direction are promising.",
author = "Yaron Tomer and Yehuda Shoenfeld",
year = "1989",
doi = "10.1016/0896-8411(89)90002-4",
language = "English (US)",
volume = "2",
pages = "739--758",
journal = "Journal of Autoimmunity",
issn = "0896-8411",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - The significance of T suppressor cells in the development of autoimmunity

AU - Tomer, Yaron

AU - Shoenfeld, Yehuda

PY - 1989

Y1 - 1989

N2 - Despite intensive research, autoimmune-disease pathogenesis is still an enigma, but in the past decade Ts-cell defects have assumed a central role in this pathogenesis. Ts-cell dysfunctions have been reported in numerous autoimmune diseases (e.g. SLE, autoimmune thyroid disease, myasthenia gravis) and in animal models of autoimmune diseases. Therefore, it is currently believed that Ts cells are responsible for maintaining self-tolerance and that perturbations in suppressor functions may initiate development of autoimmune diseases. Ts-cell abnormalities can result from LCTA production, intrinsic biochemical alterations, genetic susceptibility, or environmental factors. Since Ts-cells dysfunctions are believed to initiate autoimmunity, it may be possible to treat autoimmune diseases by correcting the suppressor defects, and indeed, preliminary trials in this direction are promising.

AB - Despite intensive research, autoimmune-disease pathogenesis is still an enigma, but in the past decade Ts-cell defects have assumed a central role in this pathogenesis. Ts-cell dysfunctions have been reported in numerous autoimmune diseases (e.g. SLE, autoimmune thyroid disease, myasthenia gravis) and in animal models of autoimmune diseases. Therefore, it is currently believed that Ts cells are responsible for maintaining self-tolerance and that perturbations in suppressor functions may initiate development of autoimmune diseases. Ts-cell abnormalities can result from LCTA production, intrinsic biochemical alterations, genetic susceptibility, or environmental factors. Since Ts-cells dysfunctions are believed to initiate autoimmunity, it may be possible to treat autoimmune diseases by correcting the suppressor defects, and indeed, preliminary trials in this direction are promising.

UR - http://www.scopus.com/inward/record.url?scp=0024839206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024839206&partnerID=8YFLogxK

U2 - 10.1016/0896-8411(89)90002-4

DO - 10.1016/0896-8411(89)90002-4

M3 - Article

C2 - 2575908

AN - SCOPUS:0024839206

VL - 2

SP - 739

EP - 758

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

IS - 6

ER -