The significance of fractionation regimens in radiation and combined hyperthermia using a murine fibrosarcoma

Eric W. Hahn, Alan A. Alfieri, Jae Ho Kim

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The significance of time‐dose relationships in the use of local tumor hyperthermia (LTH) when combined with radiation (RAD) was studied in a murine fibrosarcoma. RAD, either alone or combined with LTH, was delivered in four equal fractions (total doses, 1.8 to 4.2 krad) separated by 1 to 4 days. LTH (43.1 C ± .05 C for 15 minutes, water bath) was applied immediately after RAD. In this tumor system, RAD was most effective when delivered every 2nd or 3rd day, by a factor of 1.25 over the response achieved when the four fractions were delivered every 1 or 4 days. At all levels studied, RAD + LTH produced a superior tumor response compared to RAD alone. The ratio of the RAD + LTH/RAD doses to achieve an isobiological response ranged from 1.7 to 2.5. Most significant was the finding that the RAD + LTH treatment response was independent of the fractionation scheme used and more dependent on the total RAD dose delivered. Cancer 42:2596–2599, 1978.

Original languageEnglish (US)
Pages (from-to)2596-2599
Number of pages4
Issue number6
Publication statusPublished - Dec 1978


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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