The significance of fractionation regimens in radiation and combined hyperthermia using a murine fibrosarcoma

E. W. Hahn, A. A. Alfieri, J. H. Kim

Research output: Contribution to journalArticle

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Abstract

The significance of time-dose relationships in the use of local tumor hyperthermia (LTH) when combined with radiation (RAD) was studied in a murine fibrosarcoma. RAD, either alone or combined with LTH, was delivered in 4 equal fractions (total doses, 1.8 to 4.2 krad) separated by 1 to 4 days. LTH (43.1 C ± .05 C for 15 min, water bath) was applied immediately after RAD. In this tumor system, RAD was most effective when delivered every 2nd or 3rd day, by a factor of 1.25 over the response achieved when the 4 fractions were delivered every 1 or 4 days. At all levels studied, RAD + LTH produced a superior tumor response compared to RAD alone. The ratio of the RAD + LTH/RAD doses to achieve an isobiological response ranged from 1.7 to 2.5. Most significant was the finding that the RAD + LTH treatment response was independent of the fractionation scheme used and more dependent on the total RAD dose delivered.

Original languageEnglish (US)
Pages (from-to)2596-2599
Number of pages4
JournalCancer
Volume42
Issue number6
StatePublished - 1978
Externally publishedYes

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Fibrosarcoma
Fever
Induced Hyperthermia
Radiation
Neoplasms
Baths
Water

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The significance of fractionation regimens in radiation and combined hyperthermia using a murine fibrosarcoma. / Hahn, E. W.; Alfieri, A. A.; Kim, J. H.

In: Cancer, Vol. 42, No. 6, 1978, p. 2596-2599.

Research output: Contribution to journalArticle

Hahn, E. W. ; Alfieri, A. A. ; Kim, J. H. / The significance of fractionation regimens in radiation and combined hyperthermia using a murine fibrosarcoma. In: Cancer. 1978 ; Vol. 42, No. 6. pp. 2596-2599.
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