The role of vitamin D in the immunopathogenesis of allergic skin diseases

A. A. Benson, J. A. Toh, N. Vernon, S. P. Jariwala

Research output: Contribution to journalReview article

76 Scopus citations

Abstract

Vitamin D plays key roles in innate and adaptive immunity through the stimulation of Toll-like receptors, increasing pro-inflammatory cytokine production, and possibly enhancing T helper type 2 responses. These mechanisms may explain the growing body of evidence connecting vitamin D to allergic diseases, including asthma, food allergies, and allergic rhinitis. The data relating vitamin D to allergic skin diseases are equivocal with studies linking both high and low vitamin D levels to an increased risk of developing atopic dermatitis. In this paper, we describe the role of vitamin D in the immunopathogenesis of atopic dermatitis and other allergic skin diseases.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume67
Issue number3
DOIs
StatePublished - Mar 1 2012

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Keywords

  • atopic dermatitis
  • environment
  • epidemiology
  • urticaria
  • vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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