Abstract
Vitamin D plays key roles in innate and adaptive immunity through the stimulation of Toll-like receptors, increasing pro-inflammatory cytokine production, and possibly enhancing T helper type 2 responses. These mechanisms may explain the growing body of evidence connecting vitamin D to allergic diseases, including asthma, food allergies, and allergic rhinitis. The data relating vitamin D to allergic skin diseases are equivocal with studies linking both high and low vitamin D levels to an increased risk of developing atopic dermatitis. In this paper, we describe the role of vitamin D in the immunopathogenesis of atopic dermatitis and other allergic skin diseases.
Original language | English (US) |
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Pages (from-to) | 296-301 |
Number of pages | 6 |
Journal | Allergy: European Journal of Allergy and Clinical Immunology |
Volume | 67 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2012 |
Keywords
- atopic dermatitis
- environment
- epidemiology
- urticaria
- vitamin D
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology