The Role of the bHLH Protein Hairy in Morphogenetic Furrow Progression in the Developing Drosophila Eye

Abhishek Bhattacharya, Nicholas E. Baker

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In Drosophila eye development, a wave of differentiation follows a morphogenetic furrow progressing across the eye imaginal disc. This is subject to negative regulation attributed to the HLH repressor proteins Hairy and Extramacrochaete. Recent studies identify negative feedback on the bHLH gene daughterless as one of the main functions of extramacrochaete. Here the role of hairy was assessed in relation to daughterless and other HLH genes. Hairy was not found to regulate the expression of Daughterless, Extramacrochaete or Atonal, and Hairy expression was largely unregulated by these other genes. Null alleles of hairy did not alter the rate or pattern of differentiation, either alone or in the absence of Extramacrochaete. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete.

Original languageEnglish (US)
Article numbere47503
JournalPLoS One
Volume7
Issue number10
DOIs
StatePublished - Oct 31 2012

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Basic Helix-Loop-Helix Transcription Factors
furrows
Drosophila
Genes
eyes
Imaginal Discs
Repressor Proteins
imaginal discs
genes
null alleles
proteins
Alleles
Feedback

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The Role of the bHLH Protein Hairy in Morphogenetic Furrow Progression in the Developing Drosophila Eye. / Bhattacharya, Abhishek; Baker, Nicholas E.

In: PLoS One, Vol. 7, No. 10, e47503, 31.10.2012.

Research output: Contribution to journalArticle

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