The role of TAM family receptors and ligands in the nervous system: From development to pathobiology

Bridget Shafit-Zagardo, Ross C. Gruber, Juwen C. DuBois

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Tyro3, Axl, and Mertk, referred to as the TAM family of receptor tyrosine kinases, are instrumental in maintaining cell survival and homeostasis in mammals. TAM receptors interact with multiple signaling molecules to regulate cell migration, survival, phagocytosis and clearance of metabolic products and cell debris called efferocytosis. The TAMs also function as rheostats to reduce the expression of proinflammatory molecules and prevent autoimmunity. All three TAM receptors are activated in a concentration-dependent manner by the vitamin K–dependent growth arrest-specific protein 6 (Gas6). Gas6 and the TAMs are abundantly expressed in the nervous system. Gas6, secreted by neurons and endothelial cells, is the sole ligand for Axl. ProteinS1 (ProS1), another vitamin K–dependent protein functions mainly as an anti-coagulant, and independent of this function can activate Tyro3 and Mertk, but not Axl. This review will focus on the role of the TAM receptors and their ligands in the nervous system. We highlight studies that explore the function of TAM signaling in myelination, the visual cortex, neural cancers, and multiple sclerosis (MS) using Gas6−/− and TAM mutant mice models.

Original languageEnglish (US)
JournalPharmacology and Therapeutics
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Nervous System
Ligands
Vitamins
Cell Survival
Coagulants
Receptor Protein-Tyrosine Kinases
Visual Cortex
Autoimmunity
Phagocytosis
Multiple Sclerosis
Cell Movement
Mammals
Homeostasis
Endothelial Cells
Neurons
growth arrest-specific protein 6
Neoplasms
Proteins

Keywords

  • Axl and Mertk receptor tyrosine kinase family
  • Gas6
  • Homeostasis in the nervous system
  • Inflammation
  • Myelination
  • Phagocytosis
  • ProS1
  • Tyro3

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

The role of TAM family receptors and ligands in the nervous system : From development to pathobiology. / Shafit-Zagardo, Bridget; Gruber, Ross C.; DuBois, Juwen C.

In: Pharmacology and Therapeutics, 01.01.2018.

Research output: Contribution to journalArticle

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