The role of postoperative irradiation in the management of sphenoid wing meningiomas: A preliminary report

K. A. Peele, J. S. Kennerdell, J. C. Maroon, Shalom Kalnicki, M. Kazim, T. Gardner, M. Malton, T. Goodglick, C. Rosen, D. H. Char

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Abstract

Purpose: To determine whether postoperative radiation therapy decreases recurrence rates in subtotally excised and recurrent sphenoid wing meningiomas. Methods: Patients with primary subtotally excised and recurrent sphenoid wing meningiomas who underwent surgery between 1981 and 1994 (n = 105) were prospectively followed for recurrence. Postoperative radiation was not recommended in patients who had complete excision; therefore, their recurrence rates were not evaluated in this study. Patients with malignant meningiomas also were excluded from analysis. Recurrence was defined as evidence of tumor growth on neuroimaging with or without clinical symptoms. Results: Follow-up information was available for 86 patients: 69 had primary subtotally excised tumors and 17 had recurrent tumors. Follow-up information was unavailable in the remaining 19 patients. Tumor location and histopathology, type of surgery performed, and patient sex and age were similar in the irradiated and nonirradiated subgroups. Postoperative irradiation was delivered to 31 patients with primary tumors and 11 with recurrent tumors; none of these 42 patients had recurrence during a mean observation period of 4.2 and 3.5 years, respectively. The nonirradiated group consisted of 38 patients with primary tumors and 6 with recurrent tumors; 16 of 18 patients who had primary meningiomas had a recurrence and 5 of 6 who had recurrent tumors had another relapse (mean interval between resection and recurrence, 4.4 years and 14 months, respectively). Conclusions: Postoperative radiation appeared to delay recurrence in subtotally excised and recurrent sphenoid wing meningiomas during the time frame of this study.

Original languageEnglish (US)
Pages (from-to)1761-1767
Number of pages7
JournalOphthalmology
Volume103
Issue number11
StatePublished - 1996
Externally publishedYes

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Meningioma
Recurrence
Neoplasms
Radiation
Neuroimaging
Radiotherapy
Observation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Peele, K. A., Kennerdell, J. S., Maroon, J. C., Kalnicki, S., Kazim, M., Gardner, T., ... Char, D. H. (1996). The role of postoperative irradiation in the management of sphenoid wing meningiomas: A preliminary report. Ophthalmology, 103(11), 1761-1767.

The role of postoperative irradiation in the management of sphenoid wing meningiomas : A preliminary report. / Peele, K. A.; Kennerdell, J. S.; Maroon, J. C.; Kalnicki, Shalom; Kazim, M.; Gardner, T.; Malton, M.; Goodglick, T.; Rosen, C.; Char, D. H.

In: Ophthalmology, Vol. 103, No. 11, 1996, p. 1761-1767.

Research output: Contribution to journalArticle

Peele, KA, Kennerdell, JS, Maroon, JC, Kalnicki, S, Kazim, M, Gardner, T, Malton, M, Goodglick, T, Rosen, C & Char, DH 1996, 'The role of postoperative irradiation in the management of sphenoid wing meningiomas: A preliminary report', Ophthalmology, vol. 103, no. 11, pp. 1761-1767.
Peele KA, Kennerdell JS, Maroon JC, Kalnicki S, Kazim M, Gardner T et al. The role of postoperative irradiation in the management of sphenoid wing meningiomas: A preliminary report. Ophthalmology. 1996;103(11):1761-1767.
Peele, K. A. ; Kennerdell, J. S. ; Maroon, J. C. ; Kalnicki, Shalom ; Kazim, M. ; Gardner, T. ; Malton, M. ; Goodglick, T. ; Rosen, C. ; Char, D. H. / The role of postoperative irradiation in the management of sphenoid wing meningiomas : A preliminary report. In: Ophthalmology. 1996 ; Vol. 103, No. 11. pp. 1761-1767.
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abstract = "Purpose: To determine whether postoperative radiation therapy decreases recurrence rates in subtotally excised and recurrent sphenoid wing meningiomas. Methods: Patients with primary subtotally excised and recurrent sphenoid wing meningiomas who underwent surgery between 1981 and 1994 (n = 105) were prospectively followed for recurrence. Postoperative radiation was not recommended in patients who had complete excision; therefore, their recurrence rates were not evaluated in this study. Patients with malignant meningiomas also were excluded from analysis. Recurrence was defined as evidence of tumor growth on neuroimaging with or without clinical symptoms. Results: Follow-up information was available for 86 patients: 69 had primary subtotally excised tumors and 17 had recurrent tumors. Follow-up information was unavailable in the remaining 19 patients. Tumor location and histopathology, type of surgery performed, and patient sex and age were similar in the irradiated and nonirradiated subgroups. Postoperative irradiation was delivered to 31 patients with primary tumors and 11 with recurrent tumors; none of these 42 patients had recurrence during a mean observation period of 4.2 and 3.5 years, respectively. The nonirradiated group consisted of 38 patients with primary tumors and 6 with recurrent tumors; 16 of 18 patients who had primary meningiomas had a recurrence and 5 of 6 who had recurrent tumors had another relapse (mean interval between resection and recurrence, 4.4 years and 14 months, respectively). Conclusions: Postoperative radiation appeared to delay recurrence in subtotally excised and recurrent sphenoid wing meningiomas during the time frame of this study.",
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T1 - The role of postoperative irradiation in the management of sphenoid wing meningiomas

T2 - A preliminary report

AU - Peele, K. A.

AU - Kennerdell, J. S.

AU - Maroon, J. C.

AU - Kalnicki, Shalom

AU - Kazim, M.

AU - Gardner, T.

AU - Malton, M.

AU - Goodglick, T.

AU - Rosen, C.

AU - Char, D. H.

PY - 1996

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N2 - Purpose: To determine whether postoperative radiation therapy decreases recurrence rates in subtotally excised and recurrent sphenoid wing meningiomas. Methods: Patients with primary subtotally excised and recurrent sphenoid wing meningiomas who underwent surgery between 1981 and 1994 (n = 105) were prospectively followed for recurrence. Postoperative radiation was not recommended in patients who had complete excision; therefore, their recurrence rates were not evaluated in this study. Patients with malignant meningiomas also were excluded from analysis. Recurrence was defined as evidence of tumor growth on neuroimaging with or without clinical symptoms. Results: Follow-up information was available for 86 patients: 69 had primary subtotally excised tumors and 17 had recurrent tumors. Follow-up information was unavailable in the remaining 19 patients. Tumor location and histopathology, type of surgery performed, and patient sex and age were similar in the irradiated and nonirradiated subgroups. Postoperative irradiation was delivered to 31 patients with primary tumors and 11 with recurrent tumors; none of these 42 patients had recurrence during a mean observation period of 4.2 and 3.5 years, respectively. The nonirradiated group consisted of 38 patients with primary tumors and 6 with recurrent tumors; 16 of 18 patients who had primary meningiomas had a recurrence and 5 of 6 who had recurrent tumors had another relapse (mean interval between resection and recurrence, 4.4 years and 14 months, respectively). Conclusions: Postoperative radiation appeared to delay recurrence in subtotally excised and recurrent sphenoid wing meningiomas during the time frame of this study.

AB - Purpose: To determine whether postoperative radiation therapy decreases recurrence rates in subtotally excised and recurrent sphenoid wing meningiomas. Methods: Patients with primary subtotally excised and recurrent sphenoid wing meningiomas who underwent surgery between 1981 and 1994 (n = 105) were prospectively followed for recurrence. Postoperative radiation was not recommended in patients who had complete excision; therefore, their recurrence rates were not evaluated in this study. Patients with malignant meningiomas also were excluded from analysis. Recurrence was defined as evidence of tumor growth on neuroimaging with or without clinical symptoms. Results: Follow-up information was available for 86 patients: 69 had primary subtotally excised tumors and 17 had recurrent tumors. Follow-up information was unavailable in the remaining 19 patients. Tumor location and histopathology, type of surgery performed, and patient sex and age were similar in the irradiated and nonirradiated subgroups. Postoperative irradiation was delivered to 31 patients with primary tumors and 11 with recurrent tumors; none of these 42 patients had recurrence during a mean observation period of 4.2 and 3.5 years, respectively. The nonirradiated group consisted of 38 patients with primary tumors and 6 with recurrent tumors; 16 of 18 patients who had primary meningiomas had a recurrence and 5 of 6 who had recurrent tumors had another relapse (mean interval between resection and recurrence, 4.4 years and 14 months, respectively). Conclusions: Postoperative radiation appeared to delay recurrence in subtotally excised and recurrent sphenoid wing meningiomas during the time frame of this study.

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